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| Product | Description | |
|---|---|---|
| SU11274 | SU11274 is a selective Met inhibitor with IC 50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PKI-SU11274. CAS No. 658084-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12014. |  |
| SU11274 | SU11274 is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM. Synonyms: SU 11274; SU-11274. Grades: 0.98. CAS No. 658084-23-2. Molecular formula: C28H30ClN5O4S. Mole weight: 568.089. |  |
| NPS-1034 | NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752. Synonyms: NPS-1034; NPS1034; NPS 1034. Grades: 98%. CAS No. 1221713-92-3. Molecular formula: C31H23F2N5O3. Mole weight: 551.554. | |
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