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| Product | Description | |
|---|---|---|
| Sulfatinib | Sulfatinib, also known as surufatinib, is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1), with potential antineoplastic and anti-angiogenic activities. Upon oral administration, sulfatinib binds to and inhibits VEGFRs and FGFR1 thereby inhibiting VEGFR- and FGFR1-mediated signal transduction pathways. This leads to a reduction of angiogenesis and tumor cell proliferation in VEGFR/FGFR1-overexpressing tumor cells. Expression of VEGFRs and FGFR1 may be upregulated in a variety of tumor cell types. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HMPL012; HMPL012; HMPL 012; Sulfatinib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1308672-74-3. Molecular formula: C24H28N6O3S. Mole weight: 480.59. Purity: >98%. IUPACName: N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide. Canonical SMILES: CC1=CC2=C(N1)C=CC(OC3=NC(NC4=CC(CS(NCCN(C)C)(=O)=O)=CC=C4)=NC=C3)=C2. Product ID: ACM1308672743. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Sulfatinib | Sulfatinib, an oral drug candidate, is a small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1). Sulfatinib exhibited an acceptable safety profile and encouraging antitumor activity in patients with advanced solid tumors, particularly neuroendocrine tumors. Synonyms: N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide; HMPL012; HMPL012; HMPL 012; Sulfatinib. CAS No. 1308672-74-3. Molecular formula: C24H28N6O3S. Mole weight: 480.58. |  |
| Sulfatinib | Sulfatinib (Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3 , FGFR1 and CSF1R with IC 50 s of in a range of 1 to 24 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Surufatinib; HMPL-012. CAS No. 1308672-74-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12297. |  |
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