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| Product | Description | |
|---|---|---|
| Sumanirole maleate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Sumanirole maleate | Sumanirole maleate, also referred as PNU 95666E or U95666E, is a high affinity D2 receptor full agonist that shows >200-fold selectivity over dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively) with an ED50 of about 46 nM. Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. Synonyms: 5,6-dihydro-5-(methylamino)-4H-imidazo(4,5,1ij)-quinolin-2(1H)-one (Z)-2-butenedioate; PNU-95666; PNU95666; PNU 95666; Sumanirole; U 95666E; U-95666E; U95666E. CAS No. 179386-44-8. Molecular formula: C15H17N3O5. Mole weight: 319.31. |  |
| Sumanirole maleate | Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED 50 of about 46 nM. Sumanirole plays an important role in the research of Parkinson's disease and restless leg syndrome [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U-95666E; PNU-95666. CAS No. 179386-44-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70081A. |  |
| Sumanirole Maleate | Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits anti-Parkinsonian activity similar to Ropinirole. Group: Biochemicals. Alternative Names: (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-Butenedioate; (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-Butenedioate. Grades: Highly Purified. CAS No. 179386-43-7. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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