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| Product | Description | |
|---|---|---|
| Sunvozertinib | Sunvozertinib, also known as DZD9008, is an oral, potent, irreversible, and selective EGFR tyrosine kinase inhibitor. Sunvozertinib shows activity against EGFRexon20ins and other mutations. In both cell lines and xenograft models, sunvozertinib shows potent antitumor activity. In the two ongoing phase I clinical studies, sunvozertinib was tolerated up to 400 mg once daily. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Sunvozertinib; DZD 9008; (DZD-9008; DZD9008. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2370013-12-8. Molecular formula: C29H35ClFN7O3. Mole weight: 584.09. Purity: >98%. IUPACName: N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide. Canonical SMILES: C=CC(NC1=CC(NC2=NC=CC(NC3=CC(Cl)=C(F)C=C3C(C)(O)C)=N2)=C(OC)C=C1N4C[C@H](N(C)C)CC4)=O. Product ID: ACM2370013128. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Sunvozertinib | Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC 50 s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DZD9008. CAS No. 2370013-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132842. |  |
| Sunvozertinib | Sunvozertinib is a tyrosine kinase inhibitor with anti-tumor effects. Grades: >98%. CAS No. 2370013-12-8. Molecular formula: C29H35ClFN7O3. Mole weight: 584.1. |  |
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