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| Product | Description | |
|---|---|---|
| Syk Inhibitor II | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; 2- ( (2-Aminoethyl) amino) -4- ( (3- (trifluoromethyl) phenyl) amino) pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 726695-51-8. Molecular formula: C14H15F3N6O. Mole weight: 340.3. |  |
| Syk Inhibitor II - CAS 227449-73-2 | The Syk Inhibitor II, also referenced under CAS 227449-73-2, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Syk Inhibitor II hydrochloride | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; Syk Inhibitor II 2HCl; Syk Inhibitor II dihydrochloride; 2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide dihydrochloride. Grades: ≥98%. CAS No. 227449-73-2. Molecular formula: C14H15F3N6O·2HCl. Mole weight: 413.2. | |
| PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor) | A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Aurora Kinase Inhibitor III | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grades: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| MNS | MNS (3,4-methylenedioxy-beta-nitrostyrene) prevented platelet aggregation caused by various stimulators, and this action was accompanied by inhibition of tyrosine kinases. Synonyms: 3,4-Methylenedioxy-beta-nitrostyrene; Syk Inhibitor III; NSC 170724; 5-(2-Nitrovinyl)benzodioxole. Grades: 98%. CAS No. 1485-00-3. Molecular formula: C9H7NO4. Mole weight: 193.16. | |
| BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4- (6- (4-Isopropoxyphenyl) pyrazolo[1, 5-a]pyrimidin-3-yl) quinoline) | A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206711-16-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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