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| Product | Description | |
|---|---|---|
| SZL P1-41 | SZL P1-41. Group: Biochemicals. Grades: Purified. CAS No. 222716-34-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SZL P1-41 | SZL P1-41 is a Skp2 inhibitor that prevents assembly of Skp2-Skp1 complexes. SZL P1-41 selectively suppresses Skp2 SCF E3 ligase activity but not the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. SZL P1-41 exhibits antitumor effects in multiple animal models and cancer cell lines. Synonyms: SZL-P1-41; SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III; 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one; SKP2 E3 Ligase Inhibitor III. Grades: ≥98% by HPLC. CAS No. 222716-34-9. Molecular formula: C24H24N2O3S. Mole weight: 420.52. |  |
| SZL P1-41 | SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 222716-34-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100237. |  |
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