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| Product | Description | |
|---|---|---|
| T16Ainh-A01 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| T16Ainh-A01 | T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). T16Ainh-A01 inhibits EGF-induced increases in CaCC currents, and blocks proliferation of pancreatic cancer and squamous carcinoma cells in culture. Synonyms: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide. Grades: ≥98% by HPLC. CAS No. 552309-42-9. Molecular formula: C19H20N4O3S2. Mole weight: 416.52. |  |
| TMEM16A Inhibitor, T16Ainh-A01 (2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, ANO1 Inhibitor, T16Ainh-A01, TMEM16A Antagonist, T16Ainh-A01) | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50=1.1uM). Fully blocks CaCC current in salivary gland cells at 10uM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact at 10uM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide | 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide. Group: Biochemicals. Alternative Names: T16Ainh-A01. Grades: Highly Purified. CAS No. 552309-42-9. Pack Sizes: 10mg. Molecular Formula: C19H20N4O3S2, Molecular Weight: 416.52. US Biological Life Sciences. | Worldwide |
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