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| Product | Description | |
|---|---|---|
| TAK-441 | TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC 50 value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186231-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16475. |  |
| TAK-441 | TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway, TAK-441 is also a novel pyrrolo[3,2-c]quinoline-4-one derivative, which chemical structure is shown as the following. TAK-441 showed activity to suppress transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibited tumor growth (treatment/control ratio, 3%) in a mouse medulloblastoma allograft model owing to the improved PK profile based on increased solubility. TAK-441 is currently in clinical trials for the treatment of advanced solid tumors. Synonyms: TAK441; TAK 441. CAS No. 1186231-83-3. Molecular formula: C28H31F3N4O6. Mole weight: 576.57. |  |
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