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| Product | Description | |
|---|---|---|
| TAK-779 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TAK-779 | TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Takeda 779. CAS No. 229005-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13406. |  |
| TAK-779 | TAK-779 is a potent, dual antagonist at chemokine receptors CCR2 and CCR5 with IC50=1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and CXCR4. Synonyms: N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride, TAK-799; TAK 779; TAK779; Takeda 779. Grades: >98%. CAS No. 229005-80-5. Molecular formula: C33H39ClN2O2. Mole weight: 531.13. |  |
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