Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| TAK-960 | TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. Synonyms: TAK 960; TAK960. CAS No. 1137868-52-0. Molecular formula: C27H34F3N7O3. Mole weight: 561.61. |  |
| TAK-960 | TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) , with an IC 50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC 50 s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137868-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15160. |  |
| TAK-960-d3 | TAK-960-d3. Group: Biochemicals. Alternative Names: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: CH31D3F3N7O3, Molecular Weight: 564.62. US Biological Life Sciences. |  Worldwide |
| TAK-960 dihydrochloride | TAK-960 is an orally available, potent and selective PLK1 inhibitor that was in a phase I clinical trial in patients with advanced non-hematologic malignancies. Synonyms: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;dihydrochloride; TAK-960 (dihydrochloride); TAK 960 (dihydrochloride); TAK960 (dihydrochloride). Molecular formula: C27H36Cl2F3N7O3. Mole weight: 634.52. | |
| TAK-960 hydrochloride | The hydrochloride salt form of TAK-960, a newly studied selective PLK1 inhibitor, might have potential effect in inhibiting proliferation of sorts of cancer cell lines in vitro. The Phase-I was already discontinued for Solid tumours in USA. IC50: 1.5 nM. Uses: The hydrochloride salt form of tak-960 is a newly studied selective plk1 inhibitor and might have potential effect in inhibiting proliferation of sorts of cancer cell lines. Synonyms: TAK-960 (hydrochloride); TAK 960 hydrochloride; TAK960 hydrochloride; HY-15160A; AKOS025147360; 1137868-96-2; 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hyd. Grades: 98%. CAS No. 1137868-96-2. Molecular formula: C27H35ClF3N7O3. Mole weight: 598.06. | |
Our database is helping our users find suppliers everyday.
