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| Product | Description | |
|---|---|---|
| Talazoparib | Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Uses: For research used only. Synonyms: BMN-673; LT-673. BMN 673; LT 673. BMN673; LT673. Grades: 98%. CAS No. 1207456-01-6. Molecular formula: C19H14F2N6O. Mole weight: 380.359. |  |
| Talazoparib | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K i s of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN-673; LT-673. CAS No. 1207456-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16106. |  |
| Talazoparib-13C, d4 | Talazoparib-13C, d4. Uses: Designed for use in research and industrial production. Product ID: ACMA00049151. Alfa Chemistry ISO 9001:2015 Certified. Categories: Talazoparib-13C,d4. |  |
| Talazoparib tosylate | Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC 50 of 0.57 nM for PARP1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN 673ts. CAS No. 1373431-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-108413. | |
| BMN-673 8R,9S | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Synonyms: Talazoparib (8R,9S); (8R,9S)-BMN-673; BMN673 (8R,9S); BMN 673 (8R,9S). Grades: >98%. CAS No. 1207456-00-5. Molecular formula: C19H14F2N6O. Mole weight: 380.35. | |
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