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| Product | Description | |
|---|---|---|
| TAME | TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 901-47-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255. |  |
| TAME | TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor. Synonyms: Tosyl-L-Arginine Methyl Este. Grades: >98%. CAS No. 901-47-3. Molecular formula: C14H22N4O4S. Mole weight: 342.41. |  |
| TAME hydrochloride | TAME hydrochloride is an anaphase-promoting complex/cyclosome (APC/C) inhibitor and substrate for trypsin, thrombin, plasmin and other proteases. Synonyms: TAME HCl; TAME Hydrochloride; Ts-Arg-Me Hydrochloride; Ts-Arg-OMe Hydrchloride; N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride; methyl (2S) -5- (diaminomethylideneamino) -2-[ (4-methylphenyl) sulfonylamino]pentanoate hydrochloride. Grades: ≥99% by HPLC. CAS No. 1784-03-8. Molecular formula: C14H22N4O4S.HCl. Mole weight: 378.87. | |
| TAME hydrochloride | TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784-03-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255A. | |
| TAME Hydrochloride | A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination. Group: Biochemicals. Alternative Names: N-p-Tosyl-L-arginine methyl ester hydrochloride. Grades: Highly Purified. CAS No. 1784-03-8. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| Anaphase-Promoting Complex Inhibitor, TAME (TAME Hydrochloride) | TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50=12uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-03-8. Pack Sizes: 50mg. Molecular Formula: C??H??N?O?S · HCl, Molecular Weight: 378.87. US Biological Life Sciences. | Worldwide |
| proTAME | proTAME is a cell-permeable prodrug of N-4-tosyl-L-arginine methyl ester (TAME), which is an inhibitor of the anaphase-promoting complex/cyclosome (APC/C) suppressing its activation by Cdc20 and Cdh1. It induces mitotic arrest by activating the spindle assembly checkpoint (SAC). Synonyms: Pro-N-4-tosyl-L-arginine methyl ester; Methyl (2S) -5- [bis [ (2-phenylacetyl) oxymethoxycarbonylamino] methylideneamino] -2- [ (4-methylphenyl) sulfonylamino] pentanoate. Grades: ≥90%. CAS No. 1362911-19-0. Molecular formula: C34H38N4O12S. Mole weight: 726.75. | |
| Anaphase-Promoting Complex Inhibitor Negative Control, AAME (AAME Hydrochloride) | An acetyl-L-arginine analog of TAME that serves as a negative control. TAME is an ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-05-0. Pack Sizes: 50mg. Molecular Formula: C?H??N?O? · HCl, Molecular Weight: 266.7. US Biological Life Sciences. | Worldwide |
| Apcin | Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grades: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65. | |
| Cimetidine | Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output. Group: Biochemicals. Alternative Names: N-Cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine;Acibilin; Acinil; Biomet; Cimal; Cimetag; Cimetum; Dyspamet; Edalene; Eureceptor; Gastromet; Histodil; Peptol; SKF 92334; Tagamet; Tametin; Tratul; Ulcedin. Grades: Highly Purified. CAS No. 51481-61-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Cimetidine | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardspharma & vet compounds & metabolitespharma & vet compounds & metabolitesapi standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: N-Cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]guanidine, Ulcofalk, N-Cyano-N'-methyl-N''-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine, Cimetum, SKF 92334, Tratul, NSC 335308, Peptol, Edalene, Ulcedin, Biomet, Ulcomedina, Eureceptor, Histodil, Acibilin, Ulcerfen, Tametin, Dyspamet,Cimetidine, Cimetag, Ulcomet, Ulcimet, SKF-92334, Cimal, Tagamet, N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, Gastromet, Acinil, Ulhys, Ulcedine. |  |
| Cimetidine | United States Pharmacopeia (USP) Reference Standard. Uses: For analytical and research use. Group: Pharmacopeia & metrological institutes standards; pharma & vet compounds & metabolites; pharma & vet compounds & metabolites; api standards; british pharmacopoeia; european pharmacopoeia (ph. eur.); pharmaceutical toxicology; pharmacopoeial standards. Alternative Names: N-Cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]guanidine, Ulcofalk, N-Cyano-N'-methyl-N''-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine, Cimetum, SKF 92334, Tratul, NSC 335308, Peptol, Edalene, Ulcedin, Biomet, Ulcomedina, Eureceptor, Histodil, Acibilin, Ulcerfen, Tametin, Dyspamet,Cimetidine, Cimetag, Ulcomet, Ulcimet, SKF-92334, Cimal, Tagamet, N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, Gastromet, Acinil, Ulhys, Ulcedine. CAS No. 51481-61-9. Pack Sizes: 200MG. IUPAC Name: 2-cyano-1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine. Molecular formula: C10H16N6S. Mole weight: 252.34. Catalog: APS51481619. SMILES: CNC(=NC#N)NCCSCc1nc[nH]c1C. Format: Neat. | |
| Immobilized Trypsin, TPCK Treated (Agarose Resin) | Trypsin immobilized on beaded agarose makes it possible to eliminate enzyme contamination of tryptic digests. The trypsin can be easily removed from the digest by separating the trypsin gel from the digestion solution. The Thermo Scientific Immobilized TPCK Trypsin is treated with L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), which is a reagent that has been reported to inhibit chymotrypsin activity without effect on trypsin. Trypsin is a 23,200 molecular weight protein with a pH optimum between 7.5 and 9.0. The isoelectric points of trypsinogen and trypsin are 10.5 and 9.3, respectively. Trypsin has a wide range of applications including amino acid analys...estimated from the number of lysine and arginine residues in the protein. Ionexchange chromatography, paper electrophoresis or peptide mapping can be used to separate digestion fragments. Group: Enzymes. Synonyms: Immobilized Trypsin. Enzyme Commission Number: EC 3.4.21.4. Trypsin. Activity: > 200 TAME units per mL of gel. Storage: Upon receipt store at 4°C. Product is shipped at ambient temperature. Form: 2mL of settled gel supplied as a 50% slurry containing glycerol and 0.05% sodium azide as a preservative. Source: Bovine pancreas. Immobilized Trypsin, TPCK Treated (Agarose Resin); Immobilized Trypsin; Trypsin; Protein Fragmentation Enzymes Kits. Cat No: NATE-1867. |  |
| Trehalose octaacetate | Trehalose octaacetate, an esteemed biomedical marvel, takes center stage in combating the realm of neurodegenerative afflictions. Embarking on a noble expedition to tame the vicious Alzheimer's and Parkinson's, this formidable substance assumes the unsung role of a neuroprotective sentinel. Synonyms: 2,3,4,6,2,3,4,6-Octa-O-acetyl-a,a-trehalose. CAS No. 25018-27-3. Molecular formula: C28H38O19. Mole weight: 678.59. | |
| White Petroleum Jelly | White petroleum jelly, also known as petrolatum, is a semisolid mixture of hydrocarbons obtained from petroleum. It is a white, odorless, and tasteless substance that is commonly used for its skin-softening and lubricating properties. Uses: Skin care: White petroleum jelly is commonly used as a moisturizer and skin protectant. It is used to treat and prevent dry, chapped, or cracked skin and can be applied directly to the skin or used in products such as lotions and creams.Lip care: White petroleum jelly is often used as a lip balm to treat and prevent dry, chapped lips. It can also be used to soften and moisturize the skin around the lips.Hair care: White petroleum jelly is sometimes used to tame frizz and add shine to hair. It can also be used to protect the hair and scalp from heat damage when used as a heat protectant.First aid: White petroleum jelly is often used as a first aid treatment for minor cuts, scrapes, and burns. It can help to protect the wound and prevent infection.Other uses: White petroleum jelly may also be used as a lubricant for mechanical parts, as a protective coating for wood and metal surfaces, and as a base for some makeup products. Group: Skin Protectant. Alternative Names: Petroleum jellyVaselinePetroleum waxMineral oil jellyParaffin wax. Grades: Technical grade, Food grade, Medical grade. CAS No. 8009-3-8. |  |
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