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| Product | Description | |
|---|---|---|
| TAME hydrochloride | TAME hydrochloride is an anaphase-promoting complex/cyclosome (APC/C) inhibitor and substrate for trypsin, thrombin, plasmin and other proteases. Synonyms: TAME HCl; TAME Hydrochloride; Ts-Arg-Me Hydrochloride; Ts-Arg-OMe Hydrchloride; N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride; methyl (2S) -5- (diaminomethylideneamino) -2-[ (4-methylphenyl) sulfonylamino]pentanoate hydrochloride. Grades: ≥99% by HPLC. CAS No. 1784-03-8. Molecular formula: C14H22N4O4S.HCl. Mole weight: 378.87. |  |
| TAME hydrochloride | TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784-03-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255A. |  |
| TAME Hydrochloride | A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination. Group: Biochemicals. Alternative Names: N-p-Tosyl-L-arginine methyl ester hydrochloride. Grades: Highly Purified. CAS No. 1784-03-8. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| Anaphase-Promoting Complex Inhibitor, TAME (TAME Hydrochloride) | TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50=12uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-03-8. Pack Sizes: 50mg. Molecular Formula: C??H??N?O?S · HCl, Molecular Weight: 378.87. US Biological Life Sciences. | Worldwide |
| Anaphase-Promoting Complex Inhibitor Negative Control, AAME (AAME Hydrochloride) | An acetyl-L-arginine analog of TAME that serves as a negative control. TAME is an ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-05-0. Pack Sizes: 50mg. Molecular Formula: C?H??N?O? · HCl, Molecular Weight: 266.7. US Biological Life Sciences. | Worldwide |
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