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| Product | Description | |
|---|---|---|
| TAPI-2 | A broad spectrum inhibitor of MMPs and ADAMs (proteins containing A Disintegrin and A Metalloprotease domain). This inhibitor has been used in tissue culture (typical concentration 5-100uM). Group: Biochemicals. Alternative Names: N- (R) - (2- (Hydroxyaminocarbonyl) methyl) -4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF protease inhibitor-0, C1. Grades: Highly Purified. CAS No. 187034-31-7. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| TAPI-2 | TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE; ADAM17), other ADAMs and matrix metalloproteinases (MMPs). It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit. Synonyms: TNF Protease Inhibitor 2; N-[(2S)-1-[[(2S)-1-(2-Aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide. Grades: ≥95%. CAS No. 187034-31-7. Molecular formula: C19H37N5O5. Mole weight: 415.5. |  |
| TAPI-2 | TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease ( MMP ), tumour necrosis factor α -converting enzyme ( TACE ) and a disintegrin and metalloproteinase ( ADAM ), with an IC 50 of 20 μM for MMP [1]. TAPI-2 blocks the entry of infectious SARS-CoV [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNF Protease Inhibitor 2. CAS No. 187034-31-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100211. |  |
| TAPI-2 acetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TAPI-2 - CAS 187034-31-7 | TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes. Group: Fluorescence/luminescence spectroscopy. | |
| N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid. Group: Biochemicals. Alternative Names: TAPI-2 Acetic Acid. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C21H41N5O7, Molecular Weight: 475.58. US Biological Life Sciences. | Worldwide |
| N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide | TAPI 2 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor (Ki = 120 nM at ADAM-17). TAPI 2 sensitizes cancer stem cells to the lethal effects of 5-FU in vitro, and inhibits shedding of TNF-α from cell membranes. Synonyms: TAPI 2; TAPI2; TAPI-2; N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide; Immunex compound 1. Grades: ≥95% by HPLC. CAS No. 689284-12-6. Molecular formula: C19H37N5O5. Mole weight: 415.54. | |
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