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| Product | Description | |
|---|---|---|
| TAS4464 | TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) , with an IC 50 of 0.955 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1848959-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-128586. |  |
| TAS4464 | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Synonyms: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-. CAS No. 1848959-10-3. Molecular formula: C21H23FN6O6S. Mole weight: 506.5. |  |
| TAS4464 hydrochloride | TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) , with an IC 50 of 0.955 nM [1]. TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1848959-11-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128586A. | |
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