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| Product | Description | |
|---|---|---|
| Tat-Beclin-1 | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Synonyms: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH; Tat-BECN1. Grades: ≥95%. Molecular formula: C164H251N57O45. Mole weight: 3741.15. |  |
| Tat-Beclin-1, scrambled | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Val-Gly-Asn-Asp-Phe-Phe-Ile-Asn-His-Glu-Thr-Thr-Gly-Phe-Ala-Thr-Glu-Trp-OH. Grades: ≥95% by HPLC. Molecular formula: C164H251N57O45. Mole weight: 3741.15. | |
| Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 ((D)-H2N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO2H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II) | A cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 that is expected to be more resistant to proteolytic degradation than Tat-Beclin1 and is shown to be more potent than Tat-Beclin1 in inducing autophagy in muscle, heart, and pancreas tissues in 6-wk-old GFP-LC3 transgenic mice (20mg/kg i.p.) in vivo. Only the retro-inverso peptide, but not Tat-Beclin1, is effective in reducing autophagy substrate p26 level in the brain tissue of 5-d-old neontal GFP-LC3 mice (20mg/kg i.p.). The retro-inverso peptide treatment is also reported to greatly reduce brain viral titre in neonatal mice subjected to West Nile Virus infection. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C???H???N??O??. US Biological Life Sciences. |  Worldwide |
| Beclin-1 Activator I, TAT-Beclin-1 (Atg6 Activator I, Beclin1-GAPR-1 Interaction Blocker I, Vps30 Activator I, H2N-YGRKKRRQRRR-GG-TNVFNATFEIWHDGEFGT-CO2H) | A cell-permeable autophagy-inducing peptide (Effective conc. 30 to 100uM) that is designed based on the essential HIV-1 virulence factor Nef-binding sequence of atg6/beclin1 and N-terminally fused to the HIV-1 Tat protein transduction domain sequence. Tat-Beclin1 is reported to compete against Beclin1 for binding to its negative regulator GAPR-1/GLIPR2 on the Golgi surface. Shown to effectively induce autophagy-mediated clearance of small (<1uM) CFP-htt103Q aggregates in HeLa cells (20uM/4h/d for 2 d) and inhibit RNA viral replications both in cultures (4h 10uM peptide treatment 4h post CHIKV, SINV, or WNV infection in HeLa cultures; 24h 0.5-5uM peptide pre-treatment before HIV infection in human MDM cultures) in vitro and in mice (15-20mg/kg/day i.p.) in vivo. The in vivo bioavailability of Tat-Beclin1 is limited to the peripheral tissues in mice, while a peptide based on Tat-Beclin1 retro-inverso sequence is demonstrated to effectively target CNS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C???H???N??O??, Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly-Gly~Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH. US Biological Life Sciences. | Worldwide |
| Tat-beclin 1 | Tat-beclin 1 is a region of the autophagy protein, beclin 1, binding to HIV-1 Nef and inducing autophagy. Synonyms: Tat-BECN1. CAS No. 1423821-88-8. Molecular formula: C164H251N57O45. Mole weight: 3741.1. | |
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