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| Product | Description | |
|---|---|---|
| TC-H 106 | TC-H 106. Group: Biochemicals. Grades: Purified. CAS No. 937039-45-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TC-H 106 | TC-H 106 is a slow, tight-binding inhibitor of class I HDAC, including HDAC 1, 2, and 3 with IC50 values of 150 nM , 760nM, and 370 nM, respectively. It demonstrats no activity against class II HDACs. It inhibits these enzymes through different mechanisms. It also has preference toward HDAC3 with K(I) of approximately 14 nm, 15 times lower than the K(I) for HDAC1. It exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM. It progressively binds HDACs and remains bound after wash-out. It may have therapeutic value in Friedrich's ataxia and Huntington's disease due to their low animal toxicity. Uses: Tc-h 106 may have therapeutic value in friedrich's ataxia and huntington's disease. Synonyms: TC-H 106, TC-H106, TC-H-106, TCH-106, TCH 106, TCH106, Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106;N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide;N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide;RGFA-8;Histone Deacetylase Inhibitor VII. Grades: >99 %. CAS No. 937039-45-7. Molecular formula: C20H25N3O2. Mole weight: 339.43. |  |
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