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| Product | Description | |
|---|---|---|
| TD52 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TD52 | TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity [1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1798328-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135699. |  |
| TD52 | TD52 is an erlotinib derivative. TD52 is a putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells. TD52 induces apoptosis through downregulation of CIP2A (Cancerous inhibitor of protein phosphatase 2A) in HCC, NSCLC and TNBC cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TD52; TD-52; TD 52; erlotinib derivative; erlotinib analogue. Product Category: Inhibitors. Appearance: To be determined. CAS No. 1798328-24-1. Molecular formula: C24H16N4. Mole weight: 360.42. Purity: >98%. IUPACName: N2,N3-bis(3-ethynylphenyl)quinoxaline-2,3-diamine. Canonical SMILES: C#CC1=CC=CC(NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(C#C)=C4)=C1. Product ID: ACM1798328241. Alfa Chemistry ISO 9001:2015 Certified. Categories: TD-2. |  |
| TD52 | TD52 is a potent CIP2A inhibitor with increased apoptosis in HCC cells compared to erlotinib (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). CIP2A-dependent p-Akt downregulation modulates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo. Uses: Antitumor agent. Synonyms: N2,N3-bis(3-Ethynylphenyl)-2,3-quinoxalinediamine. Grades: 99%. CAS No. 1798328-24-1. Molecular formula: C24H16N4. Mole weight: 360.41. |  |
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