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| Product | Description | |
|---|---|---|
| Tenapanor | Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD1722; RDX5791. CAS No. 1234423-95-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15991. |  |
| Tenapanor | Tenapanor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide. Appearance: Solid. CAS No. 1234423-95-0. Molecular formula: C50H66Cl4N8O10S2. Mole weight: 1145.04. IUPACName: 1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea. Canonical SMILES: CN1C[C@H](C2=C(C1)C(=CC(=C2)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[C@@H]5CN(CC6=C5C=C(C=C6Cl)Cl)C. Product ID: ACM1234423950. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Tenapanor | This active molecular is an sodium-proton exchanger NHE3 inhibitor under the development of Ardelyx. This antiporter protein plays a really important role in sodium handling in the gastrointestinal tract and kidney and it regulates the levels of sodium absorbed and secreted by the body. Therefore, tenapanor can be useful in the treatment of chronic kidney disease and hypertension because both of them are exacerbated by excess sodium in the diet. In Oct 2016, Phase-III clinical trials in Hyperphosphataemia (in patients with end-stage renal disease) in USA was on going. Uses: Hyperphosphataemia. Synonyms: 3- ( (S) -6, 8-dichloro-2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-4-yl) -N- (26- ( (3- ( (S) -6, 8-dichloro-2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-4-yl) phenyl) sulfonamido) -10, 17-dioxo-3, 6, 21, 24-tetraoxa-9, 11, 16, 18-tetraazahexacosyl) benzenesulfonamide; AZD-1722; AZD 1722; AZD1722; RDX 5791; RDX-5791; RDX5791; Tenapanor free base. Grades: 98%. CAS No. 1234423-95-0. Molecular formula: C50H66Cl4N8O10S2. Mole weight: 1145.04. |  |
| Tenapanor HCl | Tenapanor, also known as AZD-1722 and RDX 5791, is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects. Tenapanor acts in the gastrointestinal tract to reduce the absorption of sodium and phosphate, with minimal systemic drug exposure. Synonyms: 3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(26-((3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl)sulfonamido)-10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosyl)benzenesulfonamide dihydrochloride; AZD-1722; AZD 1722; AZD1722; RDX 5791; RDX-5791; RDX5791; Tenapanor; Tenapanor hydrochloride; Tenapanor dihydrochloride. CAS No. 1234365-97-9. Molecular formula: C50H68Cl6N8O10S2. Mole weight: 1217.9. | |
| Tenapanor hydrochloride | Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD1722 hydrochloride; RDX5791 hydrochloride. CAS No. 1234365-97-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15991A. | |
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