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| Product | Description | |
|---|---|---|
| Tepotinib | Tepotinib, also known as EMD 1214063 and MSC2156119, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types. This protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Synonyms: EMD-1214063; EMD1214063; EMD 1214063; MSC-2156119; MSC2156119; MSC-2156119. CAS No. 1100598-32-0. Molecular formula: C29H28N6O2. Mole weight: 492.583. |  |
| Tepotinib | Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC 50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation and induces autophagy. Tepotinib has antitumor effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD-1214063. CAS No. 1100598-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14721. |  |
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