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| Product | Description | |
|---|---|---|
| Tetrahydrouridine | Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Tetrahydrouridine has the potential to treat tumors with highly expressed CDA as it inhibits cell proliferation through cell cycle regulation despite of cytidine deaminase expression levels deaminase (CDA). Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. Uses: Antimetabolites. Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one; NSC 112907; Tetrahydrouridine, NSC 112907; NSC-112907; NSC112907. Grades: 95%. CAS No. 18771-50-1. Molecular formula: C9H16N2O6. Mole weight: 248.23. |  |
| Tetrahydrouridine | Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase ( CDA ), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: THU; NSC-112907. CAS No. 18771-50-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15345A. |  |
| 3,4,5,6-Tetrahydrouridine (THU) | 3,4,5,6-Tetrahydrouridine, a derivative of Uridine, is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Group: Biochemicals. Alternative Names: Tetrahydro-4-hydroxy-1- β-D-ribofuranosyl-2(1H)-pyrimidinone; 1-( β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone; NSC 112907; Tetrahydrouridine. Grades: Purified. CAS No. 18771-50-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C?H??N?O?. US Biological Life Sciences. |  Worldwide |
| 5,6-Dihydrouridine | 5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%), which is a derivative of Uridine. Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Synonyms: Dihydro-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; Dihydrouridine; 1-β-D-Ribofuranosyl-hydrouracil; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(β-L-Ribofuranosyl)dihydro-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 5627-5-4. Molecular formula: C9H14N2O6. Mole weight: 246.22. | |
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