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| Product | Description | |
|---|---|---|
| Tetromycin A | An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: [1S-(1R*, 4R*, 4aR*, 6aS*, 7E, 11E, 12aS*, 15S*, 16aR*, 20aR*, 20bS*)]-4-(acetyloxy)-2, 3, 4, 4a, 6a, 9, 10, 12a, 15, 16, 20a, 20b-dodecahydro-21-hydroxy-1, 6, 7, 11, 12a, 14, 15, 20a-octamethyl-18H-16a, 19-Metheno-16aH-benzo[b]naphth[2, 1-j]oxacyclotetradecin-18, 20(1H)-dione; 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide 9-Acetate. Grades: >99% by HPLC. CAS No. 180027-83-2. Molecular formula: C36H48O6. Mole weight: 576.76. |  |
| Tetromycin A | Tetromycin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin A has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-83-2. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Tetromycin B | Tetromycin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-84-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Tetromycin B | An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide; [1S-(1R*, 4R*, 4aR*, 6aS*, 7E, 11E, 12aS*, 15S*, 16aR*, 20aR*, 20bS*)]-2, 3, 4, 4a, 6a, 9, 10, 12a, 15, 16, 20a, 20b-Dodecahydro-4, 21-trihydroxy-1, 6, 7, 11, 12a, 14, 15, 20a-octamethyl-18H-16a, 19-metheno-16aH-benzo[b]naphth[2, 1-j]oxacyclotetradecin-18, 20(1H)-dione. Grades: >99% by HPLC. CAS No. 180027-84-3. Molecular formula: C34H46O5. Mole weight: 534.73. | |
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