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| Product | Description | |
|---|---|---|
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has antiproliferative activity against PTEN-deficient tumor cell lines including prostate cancers. Synonyms: TGX221; TGX 221; 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: 98%. CAS No. 663619-89-4. Molecular formula: C21H24N4O2. Mole weight: 364.449. |  |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. |  |
| TGX-221, PI3K Inhibitor (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one) | Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase b (IC?? = 5nM for p110b). Inhibits other PI3K isoforms at higher concentrations (IC?? = 0.1uM for p110e, 5uM for p110a, and 3.5uM for p110g). Group: Biochemicals. Grades: Highly Purified. CAS No. 663619-89-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
| PI 3-K? Inhibitor VI, TGX-221 - CAS 663619-89-4 | The PI 3-K? Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. |  |
| PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFL PV-NH2) | An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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