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| Product | Description | |
|---|---|---|
| TH588 | TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH588 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TH588; TH-588; TH 588. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. Purity: >98%. IUPACName: N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine. Canonical SMILES: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1. Product ID: ACM1609960317. Alfa Chemistry ISO 9001:2015 Certified. Categories: TH 88 (MN). |  |
| TH588 | TH588 selectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells. Synonyms: TH588; TH 588; TH-588. Grades: >98%. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. |  |
| TH588 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TH588 hydrochloride | TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for cancer cell survival and is overexpressed in cancer cells. Synonyms: 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;hydrochloride; TH588 (hydrochloride); TH-588 hydrochloride; TH 588 hydrochloride; N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride; 1640282-30-9. CAS No. 1640282-30-9. Molecular formula: C13H13Cl3N4. Mole weight: 331.63. | |
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