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| Product | Description | |
|---|---|---|
| Thiostrepton | Natural antibiotic derived from Streptomyces. Group: Biochemicals. Grades: Highly Purified. CAS No. 1393-48-2. Pack Sizes: 10mg, 100mg, 500mg, 1g, 2.5g. US Biological Life Sciences. |  Worldwide |
| Thiostrepton | Thiostrepton, a kind of natural peptide thiazole antibiotic, has been found to be effective in restraining the protein synthesis and could also influence the cell cycle and lead to apoptosis in breast cancer cells. It is also resistant to gram-positive bacteria and mycobacteria. Uses: Thiostrepton is a kind of natural peptide thiazole antibiotic that has been found to be effective in restraining the protein synthesis and could also influence the cell cycle and leat to apoptosis in breast cancer cells. Synonyms: Bryamycin; Thiactin. Grades: 98%. CAS No. 1393-48-2. Molecular formula: C72H85N19O18S5. Mole weight: 1664.9. |  |
| Thiostrepton | Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation [1]. Uses: Scientific research. Group: Peptides. CAS No. 1393-48-2. Pack Sizes: 50 mg. Product ID: HY-B0990. |  |
| Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31) | Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S riobsomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistance. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor-FoxM1. Group: Biochemicals. Alternative Names: Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31. Grades: Highly Purified. CAS No. 1393-48-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Thiostrepton from Streptomyces azureus | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| 23S rRNA (adenosine1067-2'-O)-methyltransferase | The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. Group: Enzymes. Synonyms: 23S rRNA A1067 2'-methyltransferase; thiostrepton-resistance methylase; nosiheptide-resistance methyltransferase. Enzyme Commission Number: EC 2.1.1.230. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1833; 23S rRNA (adenosine1067-2'-O)-methyltransferase; EC 2.1.1.230; 23S rRNA A1067 2'-methyltransferase; thiostrepton-resistance methylase; nosiheptide-resistance methyltransferase. Cat No: EXWM-1833. |  |
| Siomycin A | A macrocyclic antibiotic first isolated from S. sioyaensis with potent and selective antibacterial activity. It is a potent inhibitor of the oncogenic transcription factor, foxm1. It inhibits foxm1-induced cell growth on soft agar and selectively kills transformed but not normal cells in vitro. Synonyms: Mutabilycin; Sporangiomycin; 6741-21; NSC 285116; Antibiotic 6741-21; (1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton; Thiostrepton, 1-Valine-2-(2,3-didehydroalanine)-. Grades: >95% by HPLC. CAS No. 12656-09-6. Molecular formula: C71H81N19O18S5. Mole weight: 1648.84. | |
| tryptophan 2-C-methyltransferase | The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a cobalamin cofactor. The enzyme first transfers the methyl group from SAM to the bound cobalamin, followed by transfer from methylcobalamin to L-tryptophan, resulting in retention of the original methyl group configuration. The second transfer is likely to involve a CH3 radical species formed from methylcobalamin by the concerted action of a partially ligated radical SAM [4Fe-4S]2+/1+ center. Group: Enzymes. Synonyms: tsrM (gene name); tryptophan 2-methyltransferase; S-adenosylmethionine:tryptophan 2-methyltransferase. Enzyme Commission Number: EC 2.1.1.106. CAS No. 126626-83-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1704; tryptophan 2-C-methyltransferase; EC 2.1.1.106; 126626-83-3; tsrM (gene name); tryptophan 2-methyltransferase; S-adenosylmethionine:tryptophan 2-methyltransferase. Cat No: EXWM-1704. | |
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