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3-Azidopropyl thioureidobenzyl DOTA is a bifunctional molecule, which can be conjugated to monoclonal antibody (mAb) and also chelate metal ion for radioimmunotherapy and PET imaging (immuno-PET). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H41N9O8S, Molecular Weight: 651.73. US Biological Life Sciences.
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3-Azidopropyl thioureidobenzyl NOTA
3-Azidopropyl thioureidobenzyl NOTA is a bifunctional molecule, which can be conjugated to monoclonal antibody (mAb) and also chelate metal ion for radioimmunotherapy and PET imaging (immuno-PET). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H34N8O6S, Molecular Weight: 550.63. US Biological Life Sciences.
1, ?3-?propyl enediisothiocy?anate is a reagent used in the synthesis of thioureido derivatives of 2-?amino-?2-?deoxy-?D-?glucose for use as N-?acetyl-? β-?D-?hexosaminidase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 52714-52-0. Pack Sizes: 250mg, 1g. Molecular Formula: C5H6N2S2, Molecular Weight: 158.24. US Biological Life Sciences.
Organocatalyst used for the asymmetric hydrocyanation of imines. Catalyst used for enantioselective iso-Pictet-Spengler Reactions. Catalyst for multicomponent Aza-Henry Reaction. Group: Heterocyclic organic compound. Alternative Names: SCHEMBL14761481; CVRDZXYJAOQFRH-XMMPIXPASA-N; MFCD18827622; 1186602-28-7; N-benzhydryl-2- (3- (3, 5-bis (trifluoromethyl) phenyl) thioureido) -N, 3, 3-trimethylbutanamide; (S) -N-benzhydryl-2- (3- (3, 5-bis (trifluoromethyl) phenyl) thioureido) -N, 3, 3-trimethylbutanamide. CAS No. 1186602-28-7. Molecular formula: C29H29F6N3OS. Mole weight: 581.621g/mol. IUPACName: (2S) -N-benzhydryl-2-[[3, 5-bis (trifluoromethyl) phenyl]carbamothioylamino]-N, 3, 3-trimethylbutanamide. Canonical SMILES: CC (C) (C)C (C (=O)N (C)C (C1=CC=CC=C1)C2=CC=CC=C2)NC (=S)NC3=CC (=CC (=C3)C (F) (F)F)C (F) (F)F. Catalog: ACM1186602287.
Apalutamide Impurity 33
Apalutamide Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 1- (3- (6-cyano-5- (trifluoromethyl) pyridin-3-yl) -1- (3-fluoro-4- (methylcarbamoyl) phenyl) thioureido) cyclobutanecarboxylate. Molecular Formula: C22H19F4N5O3S. Mole Weight: 509.11. Catalog: APB02973.
BL-918
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1). It induces cytoprotective autophagy for Parkinson's disease treatment. It protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD. Synonyms: BL 918; BL918; (R)-2- (3- (3, 5-bis (trifluoromethyl)phenyl)thioureido)-N- (2, 4-difluorophenyl)-2-phenylacetamide. Grades: ≥98%. CAS No. 2101517-69-3. Molecular formula: C23H15F8N3OS. Mole weight: 533.4.
Enzalutamide Impurity 29
Enzalutamide Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)thioureido)-2-fluoro-N-methylbenzamide. CAS No. 1798807-39-2. Molecular Formula: C17H12F4N4OS. Mole Weight: 396.36. Catalog: APB1798807392.
Kevetrin
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. Synonyms: 4-Isothioureidobutyronitrile; NSC-525990; Carbamimidothioic acid, 3-cyanopropyl ester; thioureido butyronitrile. CAS No. 500863-50-3. Molecular formula: C5H9N3S. Mole weight: 143.21.
Kevetrin hydrochloride
Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity. Uses: Inhibiting cancer cell growth and causing tumor cell apoptosis. Synonyms: UNII-NL6L2371DP; thioureidobutyronitrile; 3-cyanopropyl carbamimidothioate;hydrochloride; Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride. Grades: ≥95%. CAS No. 66592-89-0. Molecular formula: C5H10ClN3S. Mole weight: 179.66.
This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. Uses: Solid tumours. Synonyms: TAS-115; TAS 115; TAS115; 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide. Grades: 98%. CAS No. 1190836-34-0. Molecular formula: C27H23FN4O4S. Mole weight: 518.56.
Thiophanate-Methyl
Thiophanate-Methyl is a systematic fungicide of the thiophanate class. Thiophanate-Methyl is commonly used in agriculture to protect against powdery mildew, rot and other fungal diseases in fruits, vegetables and other crops. Group: Biochemicals. Alternative Names: N, N'-[1, 2-Phenylenebis (iminocarbonothioyl) ]biscarbamic Acid C,C'-Dimethyl Ester;4,4'-o-Phenylenebis[3-thioallophanic Acid Dimethyl Ester; 1,2-Bis[3-(methoxycarbonyl)-2-thioureido]benzene; 3336G; Caligran; Cercobin M 70; Cercobin Methyl; Cycosin; Dimethyl 4,4'-o-Phenylenebis(3-thioallophanate); Easout; Enovit M 70; Enovit Super; Enovit-methyl; F 6385; Fungo; Methyl topsin; Methylthiofanate; Methylthiophanate; Metoben; Mildothane; NF 44; NSC 170811; Neotopsin; Thiopan; Thiophanate methyl; Tops; Topsin 500SC; Topsin M 70WP; Topsin MD; Topsin Methyl; o-Bis(3-methoxycarbonyl-2-thioureido)benzene. Grades: Highly Purified. CAS No. 23564-05-8. Pack Sizes: 1g. US Biological Life Sciences.
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TT01001
TT01001 is a mitoNEET ligand. It acts by improving diabetes and ameliorates mitochondrial function in db/db mice. Group: Others. Alternative Names: TT01001; TT-01001; TT 01001. CAS No. 1022367-69-6. Molecular formula: C15H19Cl2N3O2S. Mole weight: 376.29. Appearance: Solid powder. Purity: >98%. IUPACName: Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate. Canonical SMILES: O=C (N1CCC (NC (NC2=CC (Cl)=CC (Cl)=C2)=S)CC1)OCC. Catalog: ACM1022367696.
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