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| Product | Description | |
|---|---|---|
| Lactosyl-b-1,1-N-octanoyl-L-threo-sphingosine | Lactosyl-b-1,1-N-octanoyl-L-threo-sphingosine is a synthetic glycosphingolipid (GSL) with nonnatural stereochemistry. It is a caveolar uptake inhibitor, which blocks SV40 virus infection. Synonyms: C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0); D-lactosyl-β1-1'-N-octanoyl-L-threo-sphingosine; C8-threo-LacCer. Grades: >99%. CAS No. 939036-94-9. Molecular formula: C38H71NO13. Mole weight: 749.97. |  |
| L-threo-sphingosine (d18:1) | L-threo-Sphingosine (d18:1), an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length. Synonyms: (2S,3S,4E)-2-aminooctadec-4-ene-1,3-diol; 3-L-4-Sphingenine. Grades: >98%. CAS No. 25695-95-8. Molecular formula: C18H37NO2. Mole weight: 299.49. | |
| 18:0(2R-OH) Sulfo GalCer Ammonium salt | The biomedical product, 18:0(2R-OH) Sulfo GalCer Ammonium salt, is a potent agent in the fight against cancer. Specifically designed as an activator in immunotherapy, this mighty compound provides a means to target and treat a range of cancers including melanoma, leukemia, and lymphoma. With a molecular conformation that allows for binding to natural killer T cells, clinical research has demonstrated a positive immune response against cancer cells. Synonyms: 3-O-sulfo-D-galactosyl-β-1,1'-N-[2''(R)-hydroxystearoyl]-D-erythro-sphingosine (ammonium salt); Ammonium (2S,3R,4E)-3-hydroxy-2-{[(2R)-2-hydroxyoctadecanoyl]amino}-4-octadecen-1-yl 3-O-sulfonato-β-D-threo-hexopyranoside. Grades: >99%. CAS No. 2260670-26-4. Molecular formula: C42H84N2O12S. Mole weight: 841.19. | |
| 18:0(2S-OH) Sulfo GalCer Ammonium salt | 18:0(2S-OH) Sulfo GalCer Ammonium salt, a synthetic compound employed in biomedical research, has the capacity to serve as a potent therapeutic agent for the treatment of various malignancies- specifically leukemia and lymphoma. Boasting versatile therapeutic potential, it has been shown to exhibit anti-inflammatory properties, and has exciting potential for the treatment of autoimmune diseases like multiple sclerosis. With its staggering attributes as a sulfo glycolipid, this intriguing compound holds tremendous promise and warrants thorough exploration in the realm of drug development. Synonyms: 3-O-sulfo-D-galactosyl-β-1,1'-N-[2''(S)-hydroxystearoyl]-D-erythro-sphingosine (ammonium salt); Ammonium (2S,3R,4E)-3-hydroxy-2-{[(2S)-2-hydroxyoctadecanoyl]amino}-4-octadecen-1-yl 3-O-sulfonato-β-D-threo-hexopyranoside; Octadecanamide, 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-β-D-threo-hexopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-, ammonium salt, (2S)-. Grades: >99%. CAS No. 2260670-28-6. Molecular formula: C42H84N2O12S. Mole weight: 841.19. | |
| C18 L-threo Ceramide (d18:1/18:0) | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grades: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| L-threo Lysosphingomyelin (d18:1) | L-threo Lysosphingomyelin (d18:1) is an endogenous bioactive sphingolipid and an agonist of sphingosine-1-phosphate (S1P) receptors 1-3. Synonyms: L-threo Lyso SM (18:1); L-threo Lysosphingomyelin (18:1); L-threo Sphingosine-1-Phosphocholine (d18:1); L-threo-Sphingosylphosphorylcholine; [(E,2S,3S)-2-amino-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Grades: ≥98%. CAS No. 105615-55-2. Molecular formula: C23H49N2O5P. Mole weight: 464.62. | |
| sphingosine kinase | The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species. Group: Enzymes. Synonyms: SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.91. CAS No. 50864-48-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3121; sphingosine kinase; EC 2.7.1.91; 50864-48-7; SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Cat No: EXWM-3121. |  |
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