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| Product | Description | |
|---|---|---|
| THZ1 | THZ1 Inhibitor. Uses: Scientific use. Product Category: T3664. CAS No. 1604810-83-4. |  |
| THZ1 | THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Synonyms: HY-80013; THZ-1; HY 80013; THZ 1; HY80013; THZ1; N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide. Grades: >98%. CAS No. 1604810-83-4. Molecular formula: C31H28ClN7O2. Mole weight: 566.062. |  |
| THZ1-R | THZ1-R, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor but has instability in vivo. Synonyms: N-[3-[[5-chloro-4- (1H-indol-3-yl) pyrimidin-2-yl]amino]phenyl]-4-[4- (dimethylamino) butanoylamino]benzamideTHZ1-R. CAS No. 1621523-07-6. Molecular formula: C31H30ClN7O2. Mole weight: 568.07. | |
| THZ2 | THZ2, an analog of THZ1, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo. IC50: CDK7= 13.9 nM; TNBC cells= 10 nM. Synonyms: N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamideTHZ2; THZ 2; THZ-2.1604810-84-5. CAS No. 1604810-84-5. Molecular formula: C31H28ClN7O2. Mole weight: 566.05. | |
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