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| Product | Description | |
|---|---|---|
| Timcodar | Timcodar, a pyridine derivative, has been found to be a p-glycoprotein inhibitor as well as nerve growth factor stimulant and was once studied in the treatment of bacterial infection and some sorts of cancers. Synonyms: Timcodar; UNII-U141W322WZ; VX853; VX853; VX 853; (2S) -N-benzyl-3- (4-chlorophenyl) -N- (1, 5-dipyridin-4-ylpentan-3-yl) -2-[methyl-[2-oxo-2- (3, 4, 5-trimethoxyphenyl) acetyl]amino]propanamide. Grades: 98%. CAS No. 179033-51-3. Molecular formula: C43H45ClN4O6. Mole weight: 749.29. |  |
| Timcodar dimesilate | Timcodar, also known as VX-853, is a Novel Multidrug Resistance Inhibitor. Timcodar was under clinical trials to treat cancaners and other diseases. Timcodar potentiated the activity of ethidium bromide (EtBr), a model efflux substrate, against three clinically significant gram-positive pathogens: Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. Similar to reserpine, VX-853 directly blocked EtBr efflux in S. aureus. Furthermore, VX-853 was effective in lowering the MICs of several clinically used antibiotics, including fluoroquinolones, suggesting that VX-853 are representatives of a new class of bacterial efflux inhibitors with the potential for use in combination therapy. Synonyms: VX-853; VX 853; VX853. CAS No. 183313-30-6. Molecular formula: C45H53ClN4O12S2. Mole weight: 941.51. | |
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