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| Product | Description | |
|---|---|---|
| Tipifarnib | A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000). Group: Biochemicals. Alternative Names: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-(+)-R 115777; Zarnestra. Grades: Highly Purified. CAS No. 192185-72-1. Pack Sizes: 2.5mg. US Biological Life Sciences. |  Worldwide |
| Tipifarnib | Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC 50 of 0.86 nM. Antineoplastic activity and antiparasitic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IND 58359; R115777. CAS No. 192185-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10502. |  |
| Tipifarnib | Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. Uses: Antineoplastic agents. Synonyms: R115777; R 115777; R-115777; LX81; NSC702818; D03720; Tipifarnib; trade name Zarnestra. Grades: 0.97. CAS No. 192185-72-1. Molecular formula: C27H22Cl2N4O. Mole weight: 489.4. |  |
| Tipifarnib S enantiomer | Tipifarnib S enantiomer is the S enantiomer of Tipifarnib. Tipifarnib, also called as Zarnestra or R115777, is a farnesyltransferase inhibitor (IC50= 0.6 nM) with antitumor activity. Synonyms: 6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Tipifarnib (S enantiomer) CHEMBL243659 tipifarnib zarnestra (S)-TIPIFARNIB tipifarnib(r115777) SCHEMBL4429738 (r)-(+)-r 115777 FT-0675247 tipifarnib(zar. CAS No. 192185-71-0. Molecular formula: C27H22Cl2N4O. Mole weight: 489.40. | |
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