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| Product | Description | |
|---|---|---|
| Tivozanib | Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951; KRN951. CAS No. 475108-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10977. |  |
| Tivozanib | Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. Check for active clinical trials or closed clinical trials using this agent. Synonyms: AV-951; AV951; AV 951; KRN951; KRN 951; KRN-951. Grades: 0.98. CAS No. 475108-18-0. Molecular formula: C22H19ClN4O5. Mole weight: 454.86306. |  |
| Tivozanib hydrate | Tivozanib hydrate (AV-951 hydrate; KRN951 hydrate) is the hydrate form of Tivozanib (HY-10977). Tivozanib hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrate exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951 hydrate; KRN951 hydrate. CAS No. 682745-40-0. Pack Sizes: 1 mg. Product ID: HY-112467. | |
| Tivozanib hydrate | Tivozanib is an orally available VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. It has been improved for the treatment of renal cell carcinoma. It also displays activity against other cancers. Synonyms: VEGFR Tyrosine Kinase Inhibitor IV; AV-951; KRN 951; 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea hydrate. Grades: ≥95%. CAS No. 682745-40-0. Molecular formula: C22H19ClN4O5·H2O. Mole weight: 472.9. | |
| Tivozanib hydrochloride hydrate | Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate. CAS No. 682745-41-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10977A. | |
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