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| Product | Description | |
|---|---|---|
| TMPA | TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK&alpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258275-73-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18555. |  |
| TMPA | TMPA is an antagonist of nuclear receptor Nur77 (Kd = 1.45 ± 0.35 μM) and LKB1 interaction. Synonyms: ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate; ethyl 2-(2,3,4-trimethoxy-6-(1-octanoyl)phenyl)acetate. CAS No. 1258275-73-8. Molecular formula: C21H32O6. Mole weight: 380.48. |  |
| Nur77 LBD Antagonist, TMPA (AMPK Signaling Activator XII, Liver Kinase B Activator, LKB1 Activator, MARK Signaling Activator, STK11 Activator, TR3 LBD Antagonist, Ethyl-2- (2, 3, 4-trimethoxy-6- (1-octanoyl) phenyl) acetate) | A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-sequestering function by antagonizing against Nur77-LKB1 interaction via direct binding at the LKB1 LBD/ligand binding domain (Kd = 0.14 against 5uM LKB1 binding to 5uM full-length Nur77). Shown to induce LKB1 Ser428 phosphorylation (10 & 20uM for 6h) and LKB1 nuclear-to-cytosol translocation in hepatic LO2 cells, resulting in enhanced phosphorylations of LKB1 cytosolic effectors AMPKalpha and MARK1/2/3 without affecting Nur77 transactivation activity. Daily i.p. dosing (50mg/kg) is shown to increase liver LKB1 Ser428/AMPKalpha Thr172 phosphorylations in diabetic db/db mice in vivo, effectively improving animal glucose tolerance. Also reported to lower fasting blood glucose level in STZ-treated, high fat diet-fed type II diabetic mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Native Human Prostatic Acid Phosphatase | Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels. Group: Enzymes. Synonyms: Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: Partially Purified. Apase. Mole weight: 100 kDa. Activity: > 200 U/mL (Dimension Clinical Chemistry System). Appearance: Cloudy, straw colored liquid. Storage: -20°C. Form: Liquid. Source: Human Semen. Species: Human. Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39. Cat No: NATE-0505. |  |
| Prostatic acid phosphatase from Human, recombinant | ACPP, also known as prostatic acid phosphatase isoform PAP, is a type I integral membrane protein of the plasma membrane and lysosomes, and a secreted form also exists. The concentration of ACPP is elevated in the circulation of prostate cancer patients, making the enzyme a marker for the progression of prostate cancer. Recombinant human ACPP, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95% by SDS-PAGE. Apase. Mole weight: 41.8 kDa. Activity: >100,000 units/mg. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: Baculovirus. Species: Human. Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Cat No: NATE-1673. | |
| Trimethyl Phosphate | Trimethyl Phosphate is used as an electrolyte additive in the synthesis of lithium ion batteries. Group: Biochemicals. Alternative Names: NSC 58985; TMP; TMPA; TMPO; Trimethoxyphosphine Oxide; Trimethyl Orthophosphate; Trimethyl Phosphate. Grades: Highly Purified. CAS No. 512-56-1. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
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