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TNP. Group: Biochemicals. Grades: Purified. CAS No. 519178-28-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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TNP
TNP is a cell-permeable inhibitor of IP6K1 and IP3K , with IC 50 values of 0.55 μM and 10.2 μM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 519178-28-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110079.
TNP
TNP is a reversible and cell-permeable inhibitor of inositol hexakisphosphate kinase (IP6K) (IC50 = 0.47 μM for inhibition of InsP7 formation) and inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Synonyms: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; IP3K Inhibitor; Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor. Grades: ≥97% by HPLC. CAS No. 519178-28-0. Molecular formula: C20H16F3N7O2. Mole weight: 443.38.
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGM-1470. CAS No. 129298-91-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-101932.
TNP-470
TNP-470 is an analog of fumagillin, an antimicrobial agent isolated from the fungus Aspergillus fumigatus. TNP-470 was shown to inhibit angiogenesis, and irreversibly suppress methionine aminopeptidase-2 (MetAP2). Uses: Angiogenesis inhibitors. Synonyms: AGM-1470; O-(Chloroacetyl-carbamoyl) Fumagillol; NSC 642492. Grades: ≥98%. CAS No. 129298-91-5. Molecular formula: C19H28ClNO6. Mole weight: 401.9.
TNP-470 (AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470)
A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2alpha phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2-100mg/kg in mice and rats; s.c.). Group: Biochemicals. Grades: Highly Purified. CAS No. 129298-91-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
TNP-ADP
TNP-ADP, the fluorescent analogue of nucleotide ADP, is frequently utilized in biomedical studies of protein conformational changes and transduction pathways activated by ADP. Its broad utility has been exemplified in the study of ADP binding interactions with proteins such as enzymes and kinases, and more importantly, probing the role of ADP in pathogenic contexts such as cardiovascular disease and various cancerous states. Synonyms: 2',3'-O-Trinitrophenyl-adenosine-5'-diphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 77450-67-0. Molecular formula: C16H15N8O16P2. Mole weight: 637.28.
TNP-AMP
TNP-AMP is a potent fluorescent probe widely employed to study adenosine receptors, which play crucial roles in various diseases, including cancer, inflammation and neurodegenerative disorders. TNP-AMP allows for visualization and quantification of adenosine receptor expression aiding in the development of novel therapies for these conditions. Synonyms: 2',3'-O-Trinitrophenyl-adenosine-5'-monophosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H14N8O13P. Mole weight: 557.3.
TNP-ATP
TNP-ATP, a formidable and discerning P2X receptor antagonist, is often exploited in biomedical research to unravel the multifaceted connections P2X receptors have in a myriad of ailments, including neuropathic pain, cancer, and inflammatory disorders. Its efficacy is wrought by dissuading ATP, a cardinal neurotransmitter radiantly integrated in cell-signaling pathways. This compound is indispensable in illuminating ATP signaling's intricacies and may prove instrumental in resolving a gamut of illnesses. Synonyms: 2',3'-O-Trinitrophenyl-adenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 120360-48-7. Molecular formula: C16H16N8O19P3. Mole weight: 717.26.
TNP-ATP triethylammonium salt
TNP-ATP triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 61368-63-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
TNP-ATP triethylammonium salt
TNP-ATP triethylammonium salt is a high affinity and selective P2X receptor antagonist with 1000-fold selectivity over P2X2, P2X4 and P2X7. It inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors (IC50 = 6, 0.9 and 7 nM, respectively). Synonyms: TNP-ATP; TNPATP; TNP ATP; TNP-ATP triethylammonium salt. 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt. Grades: ≥95% by HPLC. CAS No. 61368-63-6. Molecular formula: C16H13N8O19P3.C24H64N4. Mole weight: 1123.04.
TNP-CTP
TNP-CTP, a small molecule compound widely utilized in the biomedical domain, boasts of its exceptional capacity to stabilize RNA. Its intricate and nuanced ability to enhance protein expression has garnered significant attention in the scientific community, particularly in terms of its potential in treating debilitating diseases such as cystic fibrosis and muscular dystrophy. Impressively, TNP-CTP has also been found to augment the efficacy of specific drugs- a trait that has sparked enthusiasm amongst researchers in the field of drug discovery and development. Synonyms: 2',3'-O-Trinitrophenyl-cytidine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C15H16N6O20P3. Mole weight: 693.24.
TNP-GDP
TNP-GDP is a trinitrophenol (TNP) substituted nucleotide analog. Synonyms: 2',3'-O-Trinitrophenyl-guanosine-5'-diphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H15N8O17P2. Mole weight: 653.28.
TNP-GppNHp
TNP-GppNHp is an exceedingly sturdy GTP analogue, serving as a catalyst in instigating the activation of GTP-binding proteins, thereby affording an opportunity to scrutinize their intricate signaling cascades. Synonyms: (TNP-GMPPNP); 2',3'-O-Trinitrophenyl-guanosine-5'-[(β,γ)-imido]triphosphate, Triethylammonium salt. Grades: ≥ 90 % by HPLC. Molecular formula: C16H17N9O19P3. Mole weight: 732.28.
TNP-GTP
TNP-GTP, an analog of GTP, is a fluorescent ribose-modified ATP. TNP-GTP mimic the binding characteristics of GTP, in their interactions with various enzymes and proteins. it's spectroscopic properties make it valuable tools with which to determine the kinetic parameters of nucleotide-protein interactions. Furthermore, it acts as potentially valuable fluorescence acceptors in FRET experiments. Synonyms: 2',3'-O-Trinitrophenyl-guanosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 612837-26-0. Molecular formula: C16H16N8O20P3. Mole weight: 733.26.
Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47um for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2um). Binds to the ATP binding site of IP3K (Ki = 4.3um). Group: Biochemicals. Grades: Highly Purified. CAS No. 519178-28-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
TNP-UTP
TNP-UTP is a vital tool in biomedical research used to study RNA synthesis and modification. It is a fluorescent derivative of uridine triphosphate (UTP) and can be incorporated into RNA during transcription. TNP-UTP helps in the investigation of RNA processing and RNA-protein interactions. It aids in understanding diseases like cancer and neurodegenerative disorders at the molecular level. Synonyms: 2',3'-O-Trinitrophenyl-uridine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C15H15N5O21P3. Mole weight: 694.22.
2',3'-O-Trinitrophenyl-adenosine-5'-monophosphate triethylammonium salt
2',3'-O-Trinitrophenyl-adenosine-5'-monophosphate triethylammonium salt, a powerful and discriminatory modulator employed within the biomedical sector, serves as a fundamental research instrument. Its widespread usage revolves around the exploration of adenosine receptor activation and its implications on diverse maladies, encompassing neurodegenerative ailments and enduring pain. The distinctive attributes of this substance render it indispensable for elucidating adenosine signaling pathways and constructing targeted remedies. The compound's unwavering purity and dependable availability guarantee precise and replicable findings, augmenting the realm of biomedical investigation. Synonyms: TNP-AMP. CAS No. 807261-75-2. Molecular formula: C16H15N8O13P·x(CH3CH2)3N. Mole weight: 558.31 (free acid).
2'/3'-O-Trinitrophenyl-adenosine-5'-triphosphate triethylammonium salt
2'/3'-O-Trinitrophenyl-adenosine-5'-triphosphate triethylammonium salt. Group: Biochemicals. Alternative Names: TNP-ATP. Grades: Highly Purified. CAS No. 61368-63-6,120360-48-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H16N8O19P3. US Biological Life Sciences.
Worldwide
α-Conotoxin AuIB
α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. It shows > 100-fold selectivity over other receptor subunit combinations. Synonyms: alfa-Conotoxin AuIB; Gccsyppcfa tnpdc. CAS No. 216299-21-7. Molecular formula: C65H89N17O21S4. Mole weight: 1572.76.
Rifasutenizol
Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNP-2198. CAS No. 1001314-13-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144300.
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