Toceranib Suppliers USA
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Product | Description | |
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Toceranib Quick inquiry Where to buy Suppliers range | Toceranib (CAS 356068-94-5) is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo. Synonyms: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 356068-94-5. Molecular formula: C22H25FN4O2. Mole weight: 396.46. | |
Toceranib phosphate Quick inquiry Where to buy Suppliers range | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR&beta. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect. Synonyms: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 874819-74-6. Molecular formula: C22H28FN4O6P. Mole weight: 494.45. |