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| Product | Description | |
|---|---|---|
| Toceranib | Toceranib (CAS 356068-94-5) is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo. Synonyms: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 356068-94-5. Molecular formula: C22H25FN4O2. Mole weight: 396.46. |  |
| Toceranib | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR , VEGFR , and Kit with K i s of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU11654; PHA 291639E. CAS No. 356068-94-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-10330. |  |
| Toceranib phosphate | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR&beta. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect. Synonyms: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 874819-74-6. Molecular formula: C22H28FN4O6P. Mole weight: 494.45. | |
| Toceranib phosphate | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR , VEGFR , and Kit with K i s of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU11654 phosphate; PHA 291639E phosphate. CAS No. 874819-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10330A. | |
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