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| Product | Description | |
|---|---|---|
| Tolrestat | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. Alternative Names: N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine, Tolrestat, Lorestat,Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-, Tolrestatin, AY 27773, Alredase. |  |
| Tolrestat | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. |  |
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