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| Product | Description | |
|---|---|---|
| Torin 1 | Torin 1 Inhibitor. Uses: Scientific use. Product Category: T6045. CAS No. 1222998-36-8. |  |
| Torin 1 | Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Synonyms: Torin-1; Torin1; Torin 1. Grades: >98%. CAS No. 1222998-36-8. Molecular formula: C35H28F3N5O2. Mole weight: 607.62. |  |
| Torin 1 | Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2-10nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. Group: Biochemicals. Grades: Highly Purified. CAS No. 1222998-36-8. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. |  Worldwide |
| Torin 1 | Torin 1 is a potent inhibitor of mTOR with an IC 50 of 3 nM. Torin 1 inhibits both mTORC1 / 2 complexes with IC 50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222998-36-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13003. |  |
| Torin 2 | Torin 2. Group: Biochemicals. Alternative Names: 9- (6-Amino-3-pyridinyl) -1-[3- (trifluoromethyl) phenyl]-benzo[h]-1, 6-naphthyridin-2 (1H) -one. Grades: Highly Purified. CAS No. 1223001-51-1. Pack Sizes: 5mg. Molecular Formula: C24H15F3N4O, Molecular Weight: 432.4. US Biological Life Sciences. | Worldwide |
| Torin 2 | Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM. It inhibits ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, in PC3 cell lines respectively. It is potentially used as an antineoplastic agent. Synonyms: Torin-2; Torin2; Torin 2; 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1, 6]naphthyridin-2-one. Grades: 98%. CAS No. 1223001-51-1. Molecular formula: C24H15F3N4O. Mole weight: 432.406. | |
| mTOR Inhibitor XII, Torin2 (9- (6-aminopyridin-3-yl) -1- (3- (trifluoromethyl) phenyl) benzo[h][1, 6]naphthyridin-2 (1H) -one, DNA-PK Inhibitor VII, PI 3-K Inhibitor XIX, PI 4-K Inhibitor) | A Torin1 structural analog that acts as a cell-permeable, potent, ATP-competitive inhibitor against DNA-PK and mTOR (IC50 = 0.5 and 2.81nM, respectively). Comparing to Torin1, Torin2 displays enhanced inhibitory potency against PI 4-Kbeta (IC50 = 18.3nM) and PI 3-K (IC50 =4.68, 5.67, 8.58, 17.5, 24.5, and 28.1nM, respectively, against P110alpha/P85alpha, P110-gamma, hVPS34, P110delta/P85alpha, C2beta, C2alpha, respectively), while being more effective in inhibiting S6K1 Thr389 phosphorylation in MEF cultures (IC50 = 0.25nM vs 2nM, respectively, for Torin2 and Torin1) in vitro and displaying much improved oral bioavailability in mice (Cmax (ng/mL) /T1/2 (h) = 3968/0.72 and 223/0.79, respectively, for Torin2 and Torin1; 10/mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O, Primary Target: MTOR. US Biological Life Sciences. | Worldwide |
| mTOR Inhibitor XI, Torin1 (1- (4- (4-propionylpiperazin-1-yl) -3- (trifluoromethyl) phenyl) -9- (quinolin-3-yl) benzo[h][1, 6]naphthyridin-2 (1H) -one, DNA-PK Inhibitor VI, PI 3-K Inhibitor XVIII) | A cell-permeable pyridinonequinoline derivative that acts as a highly potent, ATP-competitive inhibibitor against mTOR and DNA-PK (IC50 = 4.32 and 6.34nM, respectively), while inhibiting PI 3-K only at much higher concentrations (IC50 =171 to 533nM). Effectively inhibits mTORC1-mediated S6K1 phosphorylation in MEF (IC50 = 2nM) in vitro, as well as mTORC2-mediated Akt and mTORC1-dependent S6 phosphorylations in murine lung and liver in vivo (up to 6h post single 20mg/kg i.p. dose). Despite its poor in vivo stability (T1/2 = 4.52h in mice; 10mg/kg i.p.), Torin1 is reported to completely suppress U87MG-derived tumor expansion in mice when administered via daily i.p. at a high dosage of 200mg/kg. Also reported to effectively inhibit cellular mTORC1 functionalities known to be rapamycin-resistant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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