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| Product | Description | |
|---|---|---|
| Tozasertib | A multikinase inhibitor once used for cancer treatment. Group: Biochemicals. Alternative Names: N- [4- [ [4- (4- methyl -1-piperazinyl) -6- [ (5- methyl -1H-pyrazol-3-yl) amino] -2-pyrimidinyl] thio] phenyl] cyclopropane carboxamide; VX 680; MK 0457. Grades: Highly Purified. CAS No. 639089-54-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Tozasertib | The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 μM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase. Synonyms: VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib. CAS No. 639089-54-6. Molecular formula: C23H28N8OS. Mole weight: 464.59. |  |
| Tozasertib | Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with K i s of 0.6, 18, 4.6 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX 680; MK-0457. CAS No. 639089-54-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-10161. |  |
| N- [4- [ [4- (4- methyl -1-piperazinyl) -6- [ (5- methyl -1H-pyrazol-3-yl) amino] -2-pyrimidinyl] thio] phenyl] cyclopropane carboxamide | N- [4- [ [4- (4- methyl -1-piperazinyl) -6- [ (5- methyl -1H-pyrazol-3-yl) amino] -2-pyrimidinyl] thio] phenyl] cyclopropane carboxamide. Group: Biochemicals. Alternative Names: Tozasertib; VX 680; MK 0457. Grades: Highly Purified. CAS No. 639089-54-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C23H28N8OS. US Biological Life Sciences. | Worldwide |
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