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| Product | Description | |
|---|---|---|
| TP0427736 | TP0427736 is a potent and selective inhibitor of ALK5 kinase activity with IC50 value of 2.72 nM. It was shown to inhibit Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with IC50 value of 8.68 nM. Synonyms: TP 0427736; TP-0427736; 6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole. CAS No. 864374-00-5. Molecular formula: C14H10N4S2. Mole weight: 298.4. |  |
| TP0427736 hydrochloride | TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC 50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC 50 =836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC 50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2459963-17-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118528A. |  |
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