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| Product | Description | |
|---|---|---|
| trans-ISRIB | trans-ISRIB. Group: Biochemicals. Grades: Purified. CAS No. 1597403-47-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| trans-ISRIB | trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. Purity: >98%. IUPACName: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide). Canonical SMILES: O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3. Product ID: ACM1597403478. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: 2- (4-chlorophenoxy) -N-[4-[[2- (4-chlorophenoxy) acetyl]amino]cyclohexyl]acetamide 2- (4-chlorophenoxy) -N- (4- (2- (4-chlorophenoxy) acetamido) cyclohexyl) acetamide ISRIB compound trans-ISRIB. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. |  |
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