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| Product | Description | |
|---|---|---|
| 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine | 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALK5 INHIBITOR I;2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE;TGF-BETA RI KINASE INHIBITOR II;TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I;2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;SJN 2511;2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;RepSox. CAS No. 446859-33-2. Molecular formula: C17H13N5. Mole weight: 287.31862. Purity: 98%+. IUPACName: 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine. Canonical SMILES: CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4. Density: 1.297g/cm³. Product ID: ACM446859332. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BIBF0775 | BIBF0775 is an inhibitor of transforming growth factor beta receptor I (TGFβRI) with an IC50 of 34 nM. Synonyms: (Z)-N-Ethyl-N-Methyl-2-Oxo-3-(Phenyl((4-(Piperidin-1-Ylmethyl)Phenyl)Amino)Methylene)Indoline-6-Carboxamide. Grade: ≥98% by HPLC. CAS No. 334951-90-5. Molecular formula: C31H34N4O2. Mole weight: 494.6. |  |
| Fresolimumab | Fresolimumab is a human monoclonal antibody targeting transforming growth factor beta (TGF-β). Fresolimumab inhibits the activity of TGF-beta, which may result in the suppression of tumor cell growth, angiogenesis, and migration. Synonyms: GC1008; GC 1008; GC-1008. CAS No. 948564-73-6. | |
| Furin from Human, Recombinant | Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells. Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It has a molecular mass of 52.7 kDa. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells. Furin cleaves precursor proteins at their paired basic amino acid processing sites. Some substrates of furin include von Willebrand factor, transforming growth factor beta 1 precursor, pro-beta-secretase and proparathyroid hormo.terial exotoxins, typically at sites marked by the consensus sequence arg-xaa-(lys/arg)-arg. Group: Enzymes. Synonyms: furin; prohormone convertase; dibasic processing enzyme; PACE; paired basic amino acid cleaving enzyme; paired basic amino acid converting enzyme; serine proteinase PACE; PC1; SPC3; proprotein convertase. Furin. Activity: > 2,000 unit/mL. Storage: -70°C. Form: buffered aqueous solution. Source: Baculovirus infected Sf9 cells. Species: Human. furin; prohormone convertase; dibasic processing enzyme; PACE; paired basic amino acid cleaving enzyme; paired basic amino acid converting enzyme; serine proteinase PACE; PC1; SPC3; proprotein convertase. Cat No: NATE-0268. |  |
| Galunisertib | Galunisertib is a potent and selective inhibitor of transforming growth factor beta receptor (TGF-βR) kinase. It was shown to inhibit self-renewal of cancer stem cells. Synonyms: LY 2157299; LY-2157299; 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide. Grade: >98%. CAS No. 700874-72-2. Molecular formula: C22H19N5O. Mole weight: 369.428. | |
| NCX 466 ((aS)-6-Methoxy-a-methyl-2-naphthalene acetic acid (5S)-5,6-bis(nitrooxy)hexyl ester) | Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-beta and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available. Group: Biochemicals. Grades: Highly Purified. CAS No. 1262956-64-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| RepSox | RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC 50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-616452; SJN 2511. CAS No. 446859-33-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13012. |  |
| TGF-beta receptor type-2 (131-139) | TGF-beta receptor type-2 (131-139) is a truncated fragment of TGF-beta receptor type-2. TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. Synonyms: Transforming Growth Factor Beta Receptor 2 (131-139); TGF-Beta Type II Receptor (131-139). | |
| UDP-Glc Dehydrogenase from Streptococcus pyogenes, Recombinant | UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene. The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Group: Enzymes. Synonyms: UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; uridine diphosphoglucose dehydrogenase; UDPG dehydrogenase; UDPG:NAD oxidoreductase; UDP-alpha-D-glucose:NAD oxidoreductase; UDP. Enzyme Commission Number: EC 1.1.1.22. CAS No. 9028-26-6. Purity: min 95% by SDS-PAGE. UDP-Glc Dehydrogenase. Source: E. coli. Species: Streptococcus pyogenes. UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; uridine diphosphoglucose dehydrogenase; UDPG dehydrogenase; UDPG:NAD oxidoreductase; UDP-alpha-D-glucose:NAD oxidoreductase; UDP-glucose:NAD+ oxidoreductase; uridine diphosphate glucose dehydrogenase; UDP-D-glucose dehydrogenase; uridine diphosphate D-glucose dehydrogenase; UDP-Glc Dehydrogenase; EC 1.1.1.22. Cat No: NATE-1501. | |
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