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Trinactin Trinactin is a tetracyclic lactone compound produced by Streptomyces. It is a monovalent cation ionophore with high selectivity to ammonium and potassium. It can inhibit the proliferation of T cells induced by IL-2, and inhibit the production of cytokines at nanomolar levels of IL-2, IL-4, IL-5 and interferon-&gamma. Synonyms: AKD-1D; S 3466B. Grades: >95% by HPLC. CAS No. 7561-71-9. Molecular formula: C43H70O12. Mole weight: 779.0. BOC Sciences 5
Trinactin (Antibiotic AKD-1D, Antibiotic S 3466B) Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp. Early literature reported that trinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nonomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Trinactin has not previously been available for intensive investigation. Group: Biochemicals. Alternative Names: Antibiotic AKD-1D, Antibiotic S 3466B. Grades: Highly Purified. CAS No. 7561-71-9. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 1
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