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| Product | Description | |
|---|---|---|
| TRO 19622 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| TRO 19622 | Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modulators. It is a molecule that has a cholesterol-like structure and displays neuroprotective properties. TRO19622 is as effective as a cocktail of three neurotrophic factors in keeping motor neurons alive in culture. Preclinical studies have demonstrated that the compound promotes the function and survival of neurons and other cell types under disease-relevant stress conditions through interactions with the mitochondrial permeability transition pore (mPTP). A 2009-2011 phase 3 clinical trial of olesoxime in amyotrophic lateral sclerosis did not demonstrate a significant increase in survival versus placebo. The results of a 2011-2013 combined phase 2/3 trial of olesoxime in spinal muscular atrophy (SMA) indicated that the compound prevents deterioration of muscle function, suggesting that olesoxime might become the first drug approved to treat SMA. Synonyms: TRO-19622; TRO19622; TRO19622; RG6083; RG 6083; RG-6083; NSC 21311; NSC-21311; NSC21311; Olesoxime. Grades: >98%. CAS No. 22033-87-0. Molecular formula: C27H45NO. Mole weight: 399.65. |  |
| TRO 19622 | TRO 19622. Group: Biochemicals. Grades: Purified. CAS No. 22033-87-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Olesoxime | Olesoxime (TRO 19622) is a mitochondrial -targeted neuroprotective compound with mean EC 50 value for increasing cell survival is 3.2±0.2 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TRO 19622; NSC 21311. CAS No. 22033-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14796. |  |
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