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| Product | Description | |
|---|---|---|
| TRV-120027 | Synthetic analogue of endogenous peptide angiotensin II. An investigational drug for the treatment of heart failure and kidney disease. Synonyms: (2R) -2-[[ (2S) -1-[ (2S) -2-[[ (2S, 3S) -2-[[ (2S) -2-[[ (2S) -2-[[ (2S) -5- (diaminomethylideneamino) -2-[[2- (methylamino) acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3- (4-hydroxyphenyl) propanoyl]amino]-3-methylpentanoyl]amino]-3- (1H-imidazol-5-yl) propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid. CAS No. 1234510-46-3. Molecular formula: C43H67N13O10. Mole weight: 926.1. |  |
| TRV-120027 | TRV120027, a β-arrestin-1 -biased agonist of the angiotensin II receptor type 1 (AT1R) , engages -arrestins while blocking G-protein signaling [1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R - β-arrestin-1 - TRPC3 - PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II - mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment [2]. Uses: Scientific research. Group: Peptides. CAS No. 1234510-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2141. |  |
| TRV-120027 acetate | TRV-120027 acetate, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling. TRV-120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV-120027 has the potential for acute decompensated heart failure (ADHF) treatment. Synonyms: H-Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH.CH3CO2H; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alanine acetic acid; D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-, acetate (1:1); TRV 027 acetate; TRV 120027 acetate; TRV120027 acetate. Grades: ≥95%. Molecular formula: C45H71N13O12. Mole weight: 986.14. | |
| TRV-120027 TFA | TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling. TRV120027 TFA inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment. Synonyms: H-Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH.TFA; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alanine trifluoroacetate; D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-, trifluoroacetate (1:1); TRV 027 trifluoroacetate; TRV 120027 trifluoroacetate; TRV120027 trifluoroacetate; TRV120027 TFA; TRV 120027 TFA. Grades: 99%. Molecular formula: C45H68F3N13O12. Mole weight: 1040.10. | |
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