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| Product | Description | |
|---|---|---|
| tryptase | Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by α1-proteinase inhibitor or α2-macroglobulin. Group: Enzymes. Synonyms: mast cell tryptase; mast cell protease II; skin tryptase; lung tryptase; pituitary tryptase; mast cell neutral proteinase; mast cell tryptase; mast cell neutral proteinase; mast cell serine proteinase II; mast cell proteinase II; mast cell serine proteinase tryptase; rat mast cell protease II; tryptase M. Enzyme Commission Number: EC 3.4.21.59. CAS No. 97501-93-4. Tryptase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4149; tryptase; EC 3.4.21.59; 97501-93-4; mast cell tryptase; mast cell protease II; skin tryptase; lung tryptase; pituitary tryptase; mast cell neutral proteinase; mast cell tryptase; mast cell neutral proteinase; mast cell serine proteinase II; mast cell proteinase II; mast cell serine proteinase tryptase; rat mast cell protease II; tryptase M. Cat No: EXWM-4149. |  |
| Tryptase from human lung | buffered aqueous solution, ?5 units/mg protein. Group: Fluorescence/luminescence spectroscopy. |  |
| Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP) | Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP). Group: Molecular Biology. US Biological Life Sciences. |  Worldwide |
| Native Human Tryptase | Tryptase is a member of the serine protease S1 family. It is the predominant neutral protease of the mast cell granules. Within the mast cell granule it exists as a heparin-stabilized active tetramer. Stabilization is a result of the high negative charge density of the glycosaminoglycan. This stabilization activity is observed with heparins with a MW > 6 kDa as well as other glycosaminoglycans such as dextran sulfate or chondroitin sulfates. Removal of heparin results in dissociation of the tetramer and inactivation of the enzyme. High concentrations of NaCl will result in the dissociation of heparin. Tryptase is a glycoprotein released from mast cells during anaphylaxis, which pe...acterized recombinant rat mast cell protease 7 expressed in pichia pastoris. tryptase has also been used in a study to investigate drug allergies in mast cell disease. Group: Enzymes. Synonyms: tryptase; mast cell tryptase; mast cell protease II; skin tryptase; lung tryptase; pituitary tryptase; mast cell neutral proteinase; mast cell tryptase; mast cell neutral proteinase; mast cell serine proteinase II; mast cell proteinase II; mast cell serine proteinase tryptase; rat mast cell protease II; tryptase M; EC 3.4.21.59. Enzyme Commission Number: EC 3.4.21.59. CAS No. 97501-93-4. Tryptase. Mole weight: Molecular Weight: ~135 kDa (Human) (Non-covalently linked tetramer with two sets o | |
| 5- (4-Methoxyphenoxy) pentanoic Acid | 5- (4-Methoxyphenoxy) pentanoic Acid is a reactant used in the preparation of PPV derivatives and precursors of thrombin and tryptase. Group: Biochemicals. Grades: Highly Purified. CAS No. 374565-57-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| AMG-126737 | AMG-126737 is a potent inhibitor of human lung mast cell tryptase (Ki = 90 nM), with greater than 10- to 200-fold selectivity versus other serine proteases. Synonyms: 3- [ [4- [5- [4- [ [ (3-carbamimidoylphenyl) sulfonylamino] methyl] phenoxy] pentoxy] phenyl] methylsulfamoyl] benzenecarboximidamide; 1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane; AMG-126737; AMG 126737; AMG126737. Grades: >98%. CAS No. 224054-76-6. Molecular formula: C33H38N6O6S2. Mole weight: 678.82. |  |
| APC 366 | APC 366, an inhibitor of tryptase, has been found to reduce airway inflammation and block postchallenge airway hyperresponsiveness in vivo. Synonyms: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide. Grades: >98%. CAS No. 158921-85-8. Molecular formula: C22H28N6O4. Mole weight: 440.5. | |
| APC 366 | APC 366 is a selective inhibitor of mast cell tryptase ( K i =7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158921-85-8. Pack Sizes: 5 mg. Product ID: HY-105999. |  |
| APC-366 hydrochloride | APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM. Synonyms: APC 366; APC 366; APC 366; AC1L42OR; N-(1-Hydroxy-2-naphthoyl)-L-arginine-L-prolinamide; 158921-85-8. Grades: 98%. CAS No. 178925-65-0. Molecular formula: C22H29ClN6O4. Mole weight: 477. | |
| APC 366 trifluoroacetate salt | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grades: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
| Benzamidine hydrochloride | Benzamidine hydrochloride is a trypsin-like serine proteases with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1670-14-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W018781. | |
| Benzamidine hydrochloride hydrate | Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Benzenecarboximidamide hydrochloride hydrate. CAS No. 206752-36-5. Pack Sizes: 5 g; 10 g. Product ID: HY-W087937. | |
| BMS 262084 | BMS 262084 is a potent and selective azetidinone-based beta-lactam tryptase inhibitor. Synonyms: (2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylic acid; BMS-262084; BMS 262084; BMS262084; CHEMBL71037; UNII-I0IR71971G; I0IR71971G; BDBM50120368; DNC004491. Grades: >98%. CAS No. 253174-92-4. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| BMS-354326 | BMS-354326 is a tryptase inhibitor with IC50 value of 1.8 nM. It has excellent selectivity against trypsin and most other related serine proteases. Synonyms: BMS-354326; BMS 354326; BMS354326; CHEMBL306448; BDBM50144532.(2S,3R)-4-oxo-1-((4-(1-oxo-6-phenylhexyl)-1-piperazinyl)carbonyl)-3-(2-(3-piperidinyl)ethyl)- 2-Azetidinecarboxylic acid. Grades: 98%. CAS No. 708258-16-6. Molecular formula: C28H40N4O5. Mole weight: 512.65. | |
| BMS-36313 | BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin. Uses: Tryptase inhibitor. Synonyms: BMS-363131; BMS 363131; BMS363131. (2S,3R)-3-[[(3R)-1-carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acid. Grades: ≥98%. CAS No. 384829-65-6. Molecular formula: C28H40N6O5. Mole weight: 540.66. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Gabexate mesylate | Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K i s of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K i s of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FOY. CAS No. 56974-61-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0385. | |
| Immobilized bovine trypsin | Immobilized bovine trypsin is ideal for digestions of proteins and peptides. Trypsin is a protease that cleaves peptide bonds at Arg and Lys. Trypsin protease is TPCK treated to remove chymotryptic activity before immobilization. Trypsin can be used to provide complementary sequence coverage when compared to chymotryptic digested samples. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Purity: >95% by SDS-PAGE analysis. Mole weight: 23300. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Bovine pancreas. Species: Bovine. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized trypsin. Cat No: NATE-1755. | |
| Immobilized human plasmin | We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form. It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG. Enzyme Commission Number: EC 3. 4. 21. 7. Purity: >95% by SDS-PAGE analysis. Mole weight: 85000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG; Immobilized plasmin. Cat No: NATE-1757. | |
| Immobilized TPCK-Trypsin on F7m | Trypsin hydrolyzes proteins, peptides, amides and esters specifically at the carboxyl groups of the basic amino acids L-arginine or L-lysine. F7m: 1. 0 mg trypsin per CR-column, immobilized on polyvinyl10,200 ST-units immobilized per CR-column. Nr. 15 Storage buffer: 50 mM Tris/HCl at pH 8. 0 at 4°CNr. 67 Reaction buffer: 50 mM phosphate at pH 8. 0Nr. 68 Washing buffer: 50 mM phosphate at pH 8. 0, 1 M NaCl. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Storage: 4 °C. Source: Bovine pancreas. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized TPCK-Trypsin; Immobilized Trypsin; TPCK-Trypsin. Cat No: NATE-1771. | |
| Immobilized TPCK-Trypsin on G3m | Trypsin hydrolyzes proteins, peptides, amides and esters specifically at the carboxyl groups of the basic amino acids L-arginine or L-lysine. G3m: 25 ug trypsin per CR-column, immobilized on dextran. 260 ST-units immobilized per CR-column. This CR-column cuts at least 50 ug tubulin per application. Nr. 15 Storage buffer: 50 mM Tris/HCl at pH 8. 0Nr. 67 Reaction buffer: 50 mM phosphate at pH 8. 0 (S?rensen)Nr. 68 Washing buffer: 50 mM phosphate at pH 8. 0, 1 M NaCl. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Storage: 4 °C. Source: Bovine pancreas. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized TPCK-Trypsin; Immobilized Trypsin; TPCK-Trypsin. Cat No: NATE-1772. | |
| Methylation modified Trypsin from Porcine, Recombinant | Trypsin specifically hydrolyzes peptide bonds at the carboxyl side of lysine and arginine residues. Recombinant trypsin is free of any other proteases activities, and TPCK is unnecessary and not contained. Unmodified trypsin is subject to auto-proteolysis, generating fragments that can interfere with protein sequencing or HPLC/MS peptides analysis. Sequencing grade modified trypsin is recombinant porcine trypsin modified by reductive methylation, rendering it resistant to proteolytic digestion. Applications: Protein digests for peptide mapping applications or protein identification by peptide mass fingerprinting or ms/ms spectral matching. it is suitable for digest...under -70°C, It is stable within 24 months.2. Above 95% activity is remained after 5 times repeated freezing and thawing.3. Above 90% activity is remained after kept under 4°C or 25°C for 24h.4. A 0.05 mg/ml solution of sequencing grade modified recombinant trypsin in 50mM NH4HCO3 is retained above 95% after a 3 hours incubation at 37 °C. For long-term such as 20hours incubation, 1mM CaCl2 is recommended to be contained. Form: Lyophilized. Source: E. coli. Species: Porcine. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Tryp | |
| Native Bovine Trypsin Acetylated | Trypsin (EC 3.4.21.4) is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to have been trypsinized. The trypsin molecule has two domains: one is related to the enzyme active site and the trypt...e bacterial multidrug atp-binding cassette transporter. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Enzyme Commission Number: EC 3.4.21.4. Trypsin. Activity: > 8,500 BAEE units/mg protein (biuret). Storage: -20°C. Source: Bovine pancreas. Species: Bovine. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Cat No: NATE-0720. | |
| Native Human Plasmin | Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products. Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Applications: A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. it has also been used in a study to investigate activation of human epithelial sodium channel (enac) by plasmin and chymotrypsin. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Enzyme Commission Number: EC 3.4.21.7. CAS No. 9001-90-5. PLG. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing sodium phosphate, mannitol, and NaCl. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Cat No: NATE-0598. | |
| Native Human Trypsin | Trypsin (EC 3.4.21.4) is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to have been trypsinized. Applications: Trypsin has been used in a study to assess the similarities between the hepatitis e virus and human astrovirus. trypsin has also been used in a study to characterize a unique technique for culturing primary adult human epithelial progenitor, or stem, cells. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; trypta. Enzyme Commission Number: EC 3.4.21.4. CAS No. 9002-7-7. Trypsin. Activity: vial of > 1 ,000 BAEE units. Storage: 2-8°C. Form: salt-free, lyophilized powder. Source: Human pancreas. Species: Human. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin. Cat No: NATE-0722. | |
| plasmin | Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin. Enzyme Commission Number: EC 3.4.21.7. CAS No. 9001-90-5. PLG. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4161; plasmin; EC 3.4.21.7; 9001-90-5; fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin. Cat No: EXWM-4161. | |
| Plasmin, Human plasma | Plasmin, Human plasma is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fibrinolysins, Human plasma; Serum tryptase, Human plasma; TAL 05-00018, Human plasma. CAS No. 9001-90-5. Pack Sizes: 100 μg; 500 μg. Product ID: HY-108883. | |
| R112 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. | |
| Syk Inhibitor VI, R406 (N4-(2,2-Dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine, 6- (5-Fluoro-2- (3, 4, 5-trimethoxyphenylamino) pyrimidin-4-ylamino) -2, 2-dimethyl-2H-pyrido[3, 2-b][1, 4]oxazin-3 (4H) -one) | A cell-permeable, orally bioavailable pyrimidinediamino compound with anti-inflammatory and anti-tumor properties. Acts as a potent, reversible and ATP-competitive inhibitor of Syk kinase (IC50 = 41nM; Ki = 30nM). Exhibits high selectivity over a broad panel of other protein kinases (300nM), ion channels, and enzymes. Blocks Syk-dependent FcR-mediated activation of monocytes/macrophages, and neutrophils and inhibits Anti-IgE-mediated degranulation in cultured human mast cells (EC50 = 56nM as measured by tryptase release). At higher concentrations, it is shown to block adenosine A3 receptors, adenosine transporter, and monoamine transporter (IC50 = 81nM, 1.84uM, and 2.74uM, respectively), and Flt3 autophosphorylation. Shown to reduce immune complex-mediated inflammation in murine models (10mg/kg) and diminish airway hyper-responsiveness in asthma models. Group: Biochemicals. Grades: Highly Purified. CAS No. 841290-80-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Trypsin from Bovine, Recombinant | Trypsin (EC 3.4.21.4) is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to have been trypsinized. Trypsin eliminates the introduction of animal source contaminants found in traditional bovin...tro production of bovine embryos. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Enzyme Commission Number: EC 3.4.21.4. CAS No. 9002-7-7. Trypsin. Activity: > 3650 units/mg solid (USP). Storage: -20°C. Form: lyophilized powder. Source: Corn. Species: Bovine. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Cat No: NATE-0724. | |
| Trypsin from Human, Recombinant | Trypsin is a member of the serine protease family. Trypsin cleaves peptides on the C-terminal end of lysine and arginine amino acid residues. The optimum pH is pH 7.0 - 8.0. The enzyme is inhibited by serine protease inhibitors, e.g. PMSF, and by metal chelating agents, e.g., EDTA.Recombinant human trypsin is a genetically engineered protein expressed in E.coli and purified by high pressure liquid chromatography. There are no contaminating enzyme activities such as carboxypeptidase A and chymotrypsin. No protease inhibitors such as PMSF are contained in the preparation. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; coc. Enzyme Commission Number: EC 3.4.21.4. CAS No. 9002-7-7. Purity: ≥ 95% by HPLC. Trypsin. Activity: >2500 USP u/mg protein. Storage: Recombinant human trypsin lyophilized should be stored under 2° C-8° C in sealed container. It is stable within 24 months. After dissolved, it should be stored under -20° C. It is stable within 24 months and above 90% activity remained after 10 times repeated freezing and thawing. Form: White or White-like lyophilized powder. Source: E. Coli. Species: Human. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Cat No: NATE-1863. | |
| Trypsin from Porcine, Recombinant | Trypsin (EC 3.4.21.4) is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to have been trypsinized. Applications: Trypsin can be used to re-suspend cells adherent to the cell culture dish wal...ring the industrial production of insulin, trypsin is necessary. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3.4.21.4; Trypsin; Acetyltrypsin. Enzyme Commission Number: EC 3.4.21.4. Purity: >90% (by SDS-PAGE). Mole weight: 24KDa (Determined by SDS-PAGE). Activity: 120 Units/mg protein. Appearance: Colorless aqueous solution. Storage: 4°C, store at -20°C/-80°C for long-term preservation?Avoid multiple freeze-thaw cycles. Form: Freeze dried powder. Source: Porcine. α-trypsin; β-trypsin; cocoonase; parenzyme; | |
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