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| Product | Description | |
|---|---|---|
| Tubacin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Tubacin | Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells. Group: Biochemicals. Alternative Names: (N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3- dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide). Grades: Highly Purified. CAS No. 537049-40-4. Pack Sizes: 500ug, 1mg, 2.5mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 721.86. US Biological Life Sciences. |  Worldwide |
| Tubacin | Tubacin was used to study the role of HDAC6 in migration and invasion of bladder cancer cells. Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. Uses: Histone deacetylase inhibitors. Synonyms: rel-N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide; Octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-. Grades: ≥95%. CAS No. 537049-40-4. Molecular formula: C41H43N3O7S. Mole weight: 721.86. |  |
| Benalaxyl | Benalaxyl is a fungicide. Benalaxyl has good control of blue mould ( Peronospora tubacina ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71626-11-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121109. |  |
| Tubastatin A HCl salt | Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. Grades: 0.98. CAS No. 1310693-92-5. Molecular formula: C20H22ClN3O2. Mole weight: 371.865. | |
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