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| Product | Description | |
|---|---|---|
| TZ9 | TZ9, a triazine compound, is a new inhibitor of human E2 enzyme which could selectively bind to the Rad6B catalytic site to restrain the ubiquitination of substrate that was related to Rad6B. It could inhibit MDA-MB-231 cell proliferation with IC50 of 6μm. Uses: Tz9, a triazine compound, is a new inhibitor of human e2 enzyme which could selectively bind to the rad6b catalytic site to restrain the ubiquitination of substrate that was related to rad6b. Synonyms: TZ9; TZ 9; TZ-9; CS-3536; CS 3536; CS3536; B4861; B 4861; B-4861. Grades: 98%. CAS No. 1002789-86-7. Molecular formula: C17H14N6O4. Mole weight: 366.33. |  |
| Rad6 Inhibitor (4-Amino-6-(phenylamino)-[1,3,5]triazin-2-yl)methyl-4-nitrobenzoate, (4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, TZ9, TZ-9, TZ 9, HHR6 Inhibitor) | A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination. Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC50 = 6uM in 72h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction. Two known cellular Rad6 substrates, beta-catenin and PCNA, are reported to be downregulated following 24h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5uM).CAS Number:002789-86-7. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: Rad6B/HHR6B. US Biological Life Sciences. |  Worldwide |
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