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| Product | Description | |
|---|---|---|
| U 46619 | U 46619. Group: Biochemicals. Grades: Purified. CAS No. 56985-40-1. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| U 46619 | U 46619 is a PGH2 (TXA2) analog that is reported to be a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U 46619 has been shown to stimulate TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. U 46619 also activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors. Synonyms: U46619, U-46619, U 46619; (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid. Grades: ≥98% by HPLC. CAS No. 56985-40-1. Molecular formula: C21H34O4. Mole weight: 350.5. |  |
| ICI 192,605 | ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Synonyms: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87. | |
| Terutroban | Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 induced increase pressure in the bronchi. Synonyms: Terutroban; S 18886; S-18886; S18886; 3-[(6R)-6-[(4-chlorophenyl)sulfonylamino]-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid3-((6R)-6-(((4-chlorophenyl)sulfonyl)amino)-2-methyl-5,6,7,8 te. CAS No. 165538-40-9. Molecular formula: C20H22ClNO4S. Mole weight: 407.91. | |
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