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U-73122 is a phospholipase C inhibitor originated by Pharmacia Corporation and IC 50 value is 1.0-2.1 μM in neutrophils and human platelets. U-73122 can be used as a tool to investigate the involvement of the PLC (phosphoinositide-specific phospholipase C) in signal transduction, especially in reseraches trying to characterize pathways leading to intracellular Ca2+ mobilization upon agonist challenge. Preclinical trials for treatment of Thrombosis was discontinued in 1998. Uses: Thrombosis. Synonyms: U-73122; U 73122; U73122; 1-(6-(((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione. Grades: 95%. CAS No. 112648-68-7. Molecular formula: C29H40N2O3. Mole weight: 464.64.
U-73122
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC 50 of 1-2.1 μM for PLC. Uses: Scientific research. Group: Signaling pathways. CAS No. 112648-68-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13419.
U-73122 - CAS 112648-68-7
U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 μM) in human platelets and neutrophils. Group: Fluorescence/luminescence spectroscopy.
U-73122 - CAS 112648-68-7
U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 μM) in human platelets and neutrophils. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 112648-68-7. Pack Sizes: 5MG. Mole weight: 464.64. Catalog: AP112648687. Assay: ?98% (HPLC).
m-3M3FBS is a direct activator of phospholipase C (PLC) that stimulates the increase in cytoplasmic calcium, inositol phosphate formation and superoxide generation in a variety of cell types. It is used in biological studies on Ca2+ homeostasis independently of phospholipase C activation. It is also used to study PLC signaling in cells and animals, often in conjunction with the PLC inhibitor U-73122. It has also been used for intracellular calcium analysis and MAP kinase assay in 293T cells. It also inhibits growth of the leukemic cell lines U937 and THP-1. Synonyms: m-3M3FBS; m 3M3FBS; m3M3FBS; 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide; N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 200933-14-8. Molecular formula: C16H16F3NO2S. Mole weight: 343.36.
o-3M3FBS
O-3M3FBS is an activator of phospholipase C (PLC). It stimulates cytoplasmic calcium increase, inositol phosphate formation and superoxide generation in humans. It is used to study PLC signaling in cells and animals in conjunction with the PLC inhibitor U-73122. It is an inactive analog of m-3M3FBS and can be used as a negative control. Synonyms: o-3M3FBS; o 3M3FBS; o3M3FBS; 2,4,6-Trimethyl-N-[2-(trifluoromethyl)phenyl]-benzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 313981-55-4. Molecular formula: C16H16F3NO2S. Mole weight: 343.36.
U-73343
U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC 50 of 1-2.1 μM for PLC [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 142878-12-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108630.
U-73343 - CAS 142878-12-4
A cell-permeable analog of U-73122 that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control. Group: Fluorescence/luminescence spectroscopy.
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