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UDP-GALNAC, a formidable and indispensable molecule in the realm of biomedicine, assumes a momentous function in the intricate maze of glycoprotein biosynthesis. It assumes the mantle of the ultimate substrate in the graceful ferrying of N-acetylgalactosamine (GalNAc) to serine or threonine residues within proteins. This mesmerizing mechanism, recognized as O-GlcNAcylation, orchestrates an orchestra of cellular processes, spanning an array of domains including cell signaling and the convoluted pathogenesis of diseases. Synonyms: UDP-N-acetyl-D-galactosamine; UDP-a-N-acetyl-D-galactosamine; Uridine diphosphate-N-acetylgalactosamine; Uridine-5'-diphosphate-alpha-D-N-acetylgalactosamine; uridine 5'-[3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyl) dihydrogen diphosphate]; Uridine 5'-(trihydrogen diphosphate), P'-(2-(acetylamino)-2-deoxy-alpha-D-galactopyranosyl) ester. Grades: 95%. CAS No. 7277-98-7. Molecular formula: C17H27N3O17P2. Mole weight: 607.35.
The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86. Group: Enzymes. Synonyms: WbnH. Enzyme Commission Number: EC 2.4.1.306. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2541; UDP-GalNAc:α-D-GalNAc-diphosphoundecaprenol α-1,3-N-acetylgalactosaminyltransferase; EC 2.4.1.306; WbnH. Cat No: EXWM-2541.
UDP-GalNAc disodium
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: UDP-N-acetyl-D-galactosamine disodium. CAS No. 108320-87-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114365.
α-1,3-N-acetyl-galactosaminyltransferase from Helicobacter mustelae, Recombinant
In enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.40) is an enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose ? UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl- (1,2)]-D-galactose. Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, [[glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-]], and [[(1,2)]-D-galactose]]. Group: Enzymes. Synonyms: UDP-N-ace. Enzyme Commission Number: EC 2.4.1.40. CAS No. 9067-69-0. Purity: min 95% by SDS-PAGE. α-1,3-N-acetyl-galactosaminyltransferase. Mole weight: 37 kDa. Source: E. coli. Species: Helicobacter mustelae. UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase; A-transferase; histo-blood group A glycosyltransferase; (Fucalpha1?2Galalpha1?3-N-acetylgalactosaminyltransferase); UDP-GalNAc:Fucalpha1?2Galalpha1?3-N-acetylgalactosaminyltransferase; alpha-3-N-acetylgalactosaminyltransferase; blood-group substance alpha-acetyltransferase; blood-group substance A-dependent acetylgalactosaminyltransferase; fucosylgalactose acetylga
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates. For explanation of the superscripted '3' in the systematic name, see GL-5.3.4. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase; globoside synthetase; UDP-N-acetylgalactosamine: globotriaosylceramide β-3-N-acetylgalactosaminyltransferase; galactosylgalactosylglucosylceramide β-D-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetylgalactosaminyltrans. Enzyme Commission Number: EC 2.4.1.79. CAS No. 62213-46-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2619; globotriaosylceramide 3-β-N-acetylgalactosaminyltransferase; EC 2.4.1.79; 62213-46-1; uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase; globoside synthetase; UDP-N-acetylgala
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors. Group: Enzymes. Synonyms: A-transferase; histo-blood group A glycosyltransferase (Fucα1?2Galα1?3-N-acetylgalactosaminyltransferase); UDP-GalNAc:Fuc&. Enzyme Commission Number: EC 2.4.1.40. CAS No. 9067-69-0. α-1,3-N-acetyl-galactosaminyltransferase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2587; glycoprotein-fucosylgalactoside α-N-acetylgalactosaminyltransferase; EC 2.4.1.40; 9067-69-0; A-transferase; histo-blood group A glycosyltransferase (Fucα1?2Galα1?3-N-acetylgalactosaminyltransferase); UDP-GalNAc:Fucα1?2Galα1?3-N-acetylgalactosaminyltransferase; α-3-N-acetylgalactosaminyltransferase; blood-group substance α-acetyltransferase; blood-group substance A-dependent acetylgalactosaminyltransferase; fucosylgalactose acetylgalactosaminyltransferase; histo-blood group A acetylgalactosaminyltransferase; histo-blood group A transferase; UDP-N-acetyl-D-galactosamine:α-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:glycoprotein-α-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase. Cat No: EXWM-2587.
hyaluronan synthase
The enzyme from Streptococcus Group A and Group C requires Mg2+.The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms. Group: Enzymes. Synonyms: spHAS; seHAS. Enzyme Commission Number: EC 2.4.1.212. CAS No. 39346-43-5. Hyaluronan synthase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2440; hyaluronan synthase; EC 2.4.1.212; 39346-43-5; spHAS; seHAS. Cat No: EXWM-2440.
polypeptide N-acetylgalactosaminyltransferase
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass. Group: Enzymes. Synonyms: protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acet. Enzyme Commission Number: EC 2.4.1.41. CAS No. 9075-15-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2588; polypeptide N-acetylgalactosaminyltransferase; EC 2.4.1.41; 9075-15-4; protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acetylgalactosaminyltransferase; polypeptide-N-acetylgalactosamine transferase; UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosami
The enzyme catalyses a step in the assembly of the repeating-unit of the O-antigen of the Gram-negative bacterium Aeromonas hydrophila AH-3. The enzyme shows no activity with UDP-N-acetyl-α-D-glucosamine (cf. EC 2.7.8.33, UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase). Group: Enzymes. Synonyms: WecP; UDP-GalNAc:polyprenol-P GalNAc-1-P transferase; UDP-GalNAc:undecaprenyl-phosphate GalNAc-1-phosphate transferase. Enzyme Commission Number: EC 2.7.8.40. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3340; UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetyl galactosaminephosphotransferase; EC 2.7.8.40; WecP; UDP-GalNAc:polyprenol-P GalNAc-1-P transferase; UDP-GalNAc:undecaprenyl-phosphate GalNAc-1-phosphate transferase. Cat No: EXWM-3340.
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