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| Product | Description | |
|---|---|---|
| Umbralisib | Umbralisib is an orally bioavailable and selective PI3K delta inhibitor that targets delta isoform with nanomolar potency, which is approximately 1000-fold selective over alpha isoform, >30-50 fold over beta isoform and >15-50 fold over gamma isoforms. Umbralisib is developed for lymphoma therapy. Synonyms: TGR-1202; TGR 1202; TGR1202; RP5264; 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one. CAS No. 1532533-67-7. Molecular formula: C31H24F3N5O3. Mole weight: 571.5. |  |
| Umbralisib | Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202; RP5264. CAS No. 1532533-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279. |  |
| Umbralisib hydrochloride | Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202 hydrochloride; RP5264 hydrochloride. CAS No. 1532533-78-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279C. | |
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